Abstract
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with poor prognosis, which is characterised by destruction of normal lung architecture and excessive deposition of lung extracellular matrix. The heterogeneity of disease progression in patients with IPF poses significant obstacles to patient care and prevents efficient development of novel therapeutic interventions. Blood biomarkers, reflecting pathobiological processes in the lung, could provide objective evidence of the underlying disease.
Longitudinally collected serum samples from the Bosentan Use in Interstitial Lung Disease (BUILD)-3 trial were used to measure four biomarkers (metalloproteinase-7 (MMP-7), Fas death receptor ligand, osteopontin and procollagen type I C-peptide), to assess their potential prognostic capabilities and to follow changes during disease progression in patients with IPF.
In baseline BUILD-3 samples, only MMP-7 showed clearly elevated protein levels compared with samples from healthy controls, and further investigations demonstrated that MMP-7 levels also increased over time. Baseline levels of MMP-7 were able to predict patients who had higher risk of worsening and, notably, baseline levels of MMP-7 could predict changes in FVC as early as month 4.
MMP-7 shows potential to be a reliable predictor of lung function decline and disease progression.
Abstract
MMP-7 is a predictive biomarker in IPF http://ow.ly/c69Y309aO4R
Footnotes
This article has supplementary material available from openres.ersjournals.com
Support statement: The work of Y. Bauer, O. Nayler, S. de Bernard, P. Cornelisse, I. Leconte, A. Morganti and S. Roux was funded by Actelion Pharmaceuticals Ltd., and the work of E.S. White was funded by US National Institutes of Health grant R01 HL109118 and funding from the Drews Sarcoidosis Research Fund. Funding information for this article has been deposited with the Crossref Funder Registry.
Conflict of interest: Disclosures can be found alongside this article at openres.ersjournals.com
- Received July 6, 2016.
- Accepted December 31, 2016.
- Copyright ©ERS 2017
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