Extract
A lack of correlation between systemic and local IgE production at mucosal sites has been reported for allergic asthma [1–5], allergic rhinitis [6, 7] and chronic rhinosinusitis with nasal polyps [8–10]. In allergic asthmatics, local IgE production is higher than in nonallergic asthmatics [3] and high local IgE levels have been linked to the clinical phenotype. Interestingly, in cases of nasal polyps, local IgE targets mainly superantigens [8].
Abstract
IgE responses to Aspergillus fumigatus in cystic fibrosis lungs http://ow.ly/XXwv30furqs
Acknowledgments
T. Eiwegger was involved in the conception, hypotheses delineation and design of the study. E. Nachbaur, Z. Szépfalusi, T. Eiwegger, J. Argeny, S. Kanolzer, K. Schmidthaler, P. Fucik, M. Goña-Höpler, R. Crameri, A.G. Glaser, C. Rhyner and M. Debiasi were involved in acquisition, analysis and interpretation of the data. M. Goña-Höpler and B. Pfaller were involved in analysis and writing the article. S. Renner, E. Nachbaur, Z. Szépfalusi and T. Eiwegger were involved in critical review of the manuscript.
Footnotes
Support statement: Supported by funds of the Oesterreichische Nationalbank (Anniversary Fund, project number 13846ONB) and the Medical Scientific Fund of the Mayor of the City of Vienna (number 11013). Work at SIAF was supported by Swiss National Science Foundation Grants 320030_149978/1 and 31NM_152038. Funding information for this article has been deposited with the Crossref Funder Registry.
Conflict of interest: None declared.
- Received May 31, 2017.
- Accepted September 7, 2017.
- Copyright ©ERS 2017
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