Extract
The term interstitial lung abnormalities (ILA) was coined to define a precursory stage of idiopathic pulmonary fibrosis and encompasses a set of radiological changes seen in interstitial lung diseases (ILD) but are often of lesser magnitude [1]. ILA have been associated with age, many environmental and genetic risk factors and pulmonary symptoms of idiopathic pulmonary fibrosis [1, 2]. ILA have also been associated with reduced exercise capacity and self-reported health and function [3–5].
Abstract
Reductions in objectively measured physical function are associated with interstitial lung abnormalities http://ow.ly/azAW30kMhqv
Footnotes
Author Contributions: G. Gudmundsson, V. Gudnason, H. Hatabu and G.M. Hunninghake designed the study; T. Araki, T. Aspelund, G.T. Axelsson, G. Eiríksdottír, E.F. Gudmundsson, G. Gudmundsson, V. Gudnason, H. Hatabu, G.M. Hunninghake, R.K. Putman, K. Siggeirsdottir and S. Sigurdsson acquired, analysed or interpreted the data; T. Araki, T. Aspelund, G.T. Axelsson, G. Eiríksdottír, E.F. Gudmundsson, G. Gudmundsson, V. Gudnason, T.B. Harris, H. Hatabu, G.M. Hunninghake, L.J. Launer, E.R. Miller, R.K. Putman and S. Sigurdsson critically revised the manuscript for important intellectual content; G.T. Axelsson, G.M. Hunninghake and R.K. Putman performed statistical analysis; and G. Gudmundsson, V. Gudnason and G.M. Hunninghake obtained funding.
Conflict of interest: H. Hatabu reports receiving grants from Toshiba Medical Systems Inc. and Konica-Minolta Inc., and has served on an advisory board for Toshiba Medical System Inc., outside the submitted work.
Conflict of interest: G.M. Hunninghake reports receiving personal fees from Genentech, Boehringer Ingelheim and the Gerson Lehrman Group, outside the submitted work.
Support statement: R.K. Putman is supported by a National Institutes of Health (NIH) grant (T32 HL007633). G. Gudmundsson is supported by a project grant from the Icelandic Research Fund (141513–051) and from the Landspitali Scientific Fund (A-2015–030 and A-2016-023). The AGES (Age, Gene/Environment Susceptibility)-Reykjavik study was supported by a National Institute on Aging (NIA) grant (27120120022C), two NIH contracts (N01-AG-1-2100 and HHSN27120120022C), the NIA Intramural Research Program, Hjartavernd (the Icelandic Heart Association) and the Althingi (the Icelandic Parliament). V. Gudnason is supported by an NIA grant (27120120022C) and an Icelandic Research Fund project grant (141513-051). G.M. Hunninghake is supported by NIH grants (P01 HL114501, R01 HL111024, R01 HL135142 and RO1 HL130974) and a project grant from the Icelandic Research Fund (141513-051). Funding information for this article has been deposited with the Crossref Funder Registry.
- Received February 13, 2018.
- Accepted July 1, 2018.
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