Extract
Recent clinical studies have revealed that reappearance of the same nontuberculous mycobacterium (NTM) infection is common after successful standard treatment [1, 2]. Using pulsed-field gel electrophoresis analysis, Wallace et al. [1] found that ∼75% of Mycobacterium avium-intracellulare complex (MAC) isolates identified after successful treatment are the result of reinfection. According to a recent study conducted by Koh et al. [2] using repetitive sequence-based PCR analysis, all re-identified M. abscessus subsp. abscessus isolates had a unique genotype. Therefore, patients with NTM are exposed to large amounts of microbes in their daily lives, particularly in cases of reinfection.
Abstract
Reinfection of nontuberculous mycobacterium pulmonary disease may be caused by identical and not different genotypes http://ow.ly/62cH30krdpa
Acknowledgements
The authors express their sincere appreciation to Masaru Nakagawa (Nakagawa Internal Medicine –Pediatrics Clinic, Fujimi city, Japan) for his valuable advice.
Footnotes
Conflict of interest: None declared.
This work was supported by the Research Program on Emerging and Re-emerging Infectious Diseases from the Japan Agency for Medical Research and Development, AMED under grant number JP18fk0108043. Funding information for this article has been deposited with the Crossref Funder Registry.
- Received November 21, 2017.
- Accepted May 29, 2018.
- Copyright ©ERS 2018
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