Any wheezing between one and 6 years¶ (n=105/322) |
Reference phenotypes | | | | | | |
Phenotype 1 (baseline; n=147) | 1 | Reference | | 1 | Reference | |
Phenotype 2 (n=128) | 2.14 | 1.26–3.62 | 0.005 | 1.93 | 1.11–3.35 | 0.019 |
Phenotype 3 (n=47) | 3.61 | 1.81–7.19 | <0.001 | 2.84 | 1.32–6.11 | 0.008 |
Symptom dynamic phenotypes | | | | | | |
Phenotype 1 (baseline; n=145) | 1 | Reference | | 1 | Reference | |
Phenotype 2 (n=135) | 1.07 | 0.63–1.79 | 0.809 | 1.06 | 0.61–1.84 | 0.830 |
Phenotype 3 (n=42) | 4.72 | 2.27–9.72 | <0.001 | 4.31 | 1.95–9.48 | <0.001 |
Risk factors | | | | | | |
Male sex | 3.05 | 1.86–5.01 | <0.001 | 2.90 | 1.75–4.81 | <0.001 |
Siblings | 1.22 | 0.77–1.95 | 0.386 | 1.27 | 0.78–2.09 | 0.328 |
Maternal asthma | 2.23 | 1.09–4.58 | 0.028 | 2.16 | 1.03–4.55 | 0.041 |
Childcare | 1.49 | 0.84–2.64 | 0.169 | 1.40 | 0.75–2.59 | 0.284 |
Parental smoking during infancy | 1.08 | 0.61–1.89 | 0.783 | 0.99 | 0.55–1.81 | 0.995 |
Low maternal education | 1.23 | 0.76–2.01 | 0.391 | 1.13 | 0.66–1.93 | 0.644 |
Current wheezing at 6 years+ (n=38/322) | | | | | | |
Reference phenotypes | | | | | | |
Phenotype 1 (baseline; n=147) | 1 | Reference | | 1 | Reference | |
Phenotype 2 (n=128) | 1.36 | 0.62–2.99 | 0.433 | 1.22 | 0.54–2.75 | 0.618 |
Phenotype 3 (n=47) | 2.78 | 1.13–6.86 | 0.026 | 2.25 | 0.83–6.11 | 0.110 |
Symptom dynamic phenotypes | | | | | | |
Phenotype 1 (baseline; n=145) | 1 | Reference | | 1 | Reference | |
Phenotype 2 (n=135) | 0.99 | 0.45–2.21 | 0.994 | 1.01 | 0.44–2.31 | 0.968 |
Phenotype 3 (n=42) | 3.32 | 1.37–8.01 | 0.008 | 3.01 | 1.15–7.88 | 0.025 |
Risk factors | | | | | | |
Male sex | 2.52 | 1.21–5.28 | 0.014 | 2.26 | 1.06–4.81 | 0.033 |
Siblings | 1.15 | 0.58–2.28 | 0.670 | 1.19 | 0.61–2.42 | 0.616 |
Maternal asthma | 1.71 | 0.65–4.45 | 0.141 | 1.66 | 0.62–4.41 | 0.306 |
Childcare | 1.35 | 0.61–3.02 | 0.462 | 1.38 | 0.58–3.27 | 0.457 |
Parental smoking during infancy | 1.33 | 0.61–2.89 | 0.468 | 1.15 | 0.51–2.59 | 0.723 |
Low maternal education | 1.77 | 0.82–3.78 | 0.141 | 1.63 | 0.73–3.66 | 0.229 |
Atopic disease at 6 years§ (n=120/320) | | | | | | |
Reference phenotypes | | | | | | |
Phenotype 1 (baseline; n=146) | 1 | Reference | | 1 | Reference | |
Phenotype 2 (n=127) | 1.13 | 0.69–1.86 | 0.602 | 1.06 | 0.63–1.78 | 0.824 |
Phenotype 3 (n=47) | 0.99 | 0.51–1.97 | 0.987 | 0.89 | 0.41–1.91 | 0.772 |
Symptom dynamic phenotypes | | | | | | |
Phenotype 1 (baseline; n=144) | 1 | Reference | | 1 | Reference | |
Phenotype 2 (n=135) | 1.07 | 0.65–1.74 | 0.778 | 1.12 | 0.66–1.88 | 0.667 |
Phenotype 3 (n=41) | 1.57 | 0.78–3.17 | 0.205 | 1.74 | 0.81–3.77 | 0.159 |
Risk factors | | | | | | |
Male sex | 2.15 | 1.35–3.42 | 0.001 | 2.10 | 1.29–3.40 | 0.003 |
Siblings | 1.09 | 0.69–1.72 | 0.686 | 1.01 | 0.63–1.63 | 0.944 |
Maternal asthma | 1.55 | 0.76–3.18 | 0.226 | 1.51 | 0.72–3.17 | 0.274 |
Childcare | 0.62 | 0.34–1.14 | 0.127 | 0.63 | 0.33–1.21 | 0.168 |
Parental smoking during infancy | 1.09 | 0.63–1.88 | 0.752 | 0.92 | 0.55–1.64 | 0.786 |
Low maternal education | 2.30 | 1.40–3.77 | 0.001 | 2.03 | 1.20–3.41 | 0.008 |