Abstract
COVID pneumonitis can cause patients to become critically ill. They may require intensive care and mechanical ventilation. Ventilator-associated pneumonia (VAP) is a concern. This review discusses VAP in this group. Several reasons have been proposed to explain the elevated rates of VAP in critically ill COVID patients compared to non-COVID patients. Extrinsic factors include understaffing, lack of personal protective equipment and use of immunomodulating agents. Intrinsic factors include severe parenchymal damage and immune dysregulation, along with pulmonary vascular endothelial inflammation and thrombosis. The rate of VAP has been reported at 45.4%, with an intensive care unit mortality rate of 42.7%. Multiple challenges to diagnosis exist. Other conditions such as acute respiratory distress syndrome, pulmonary oedema and atelectasis can present with similar features. Frequent growth of gram-negative bacteria has been shown in multiple studies, with particularly high rates of Pseudomonas aeruginosa. The rate of invasive pulmonary aspergillosis has been reported at 4–30%. We would recommend the use of invasive techniques when possible. This will enable de-escalation of antibiotics as soon as possible, decreasing overuse. It is also important to keep other possible causes of VAP in mind, e.g. COVID-19-associated pulmonary aspergillosis or cytomegalovirus. Diagnostic tests such as galactomannan and β-D-glucan should be considered. These patients may face a long treatment course, with risk of re-infection, along with prolonged weaning, which carries its own long-term consequences.
Abstract
Critically ill COVID-19 patients are at risk of developing VAP for several reasons. This increases their overall mortality. Although challenging, early identification of the causative organism through invasive techniques is advised. https://bit.ly/3vCatYv
Introduction
The COVID-19 pandemic has taken the world by storm. Intensive care units (ICU) across the globe have been put under extreme pressure. Although the global COVID-19 pandemic has lasted over 2 years at the time of writing, ventilator-associated pneumonia (VAP) (pneumonia that occurs 48 h post intubation or longer [1]) is still posing a challenge to intensive care clinicians now. The estimated mortality rate of VAP in COVID patients is 42.7% [1]. An increase in the number of patients requiring intensive care has been shown. These patients go on to require invasive ventilation with prolonged ICU stays. As a result, these patients are at substantial risk of developing VAP.
This review discusses the topic of VAP in adult patients with COVID-19 pneumonitis requiring invasive mechanical ventilation. The risk factors, prevalence, diagnostic challenges and aetiology will be detailed. Prevention, treatment and stewardship will be examined. Weaning, re-infection and long-term outcomes of VAP in critically ill COVID patients will be discussed.
Using the terms “ventilator-associated pneumonia”, “VAP”, “COVID” and “ICU”, a search was carried out to identify suitable publications to include in this review. The following databases were used: PubMed, Embase, Annual Reviews, Biomedical Central Journals Complete, Cochrane Database of Systematic Reviews, Cochrane Database and JAMA Network. Only articles written in English were included. This is intended to be a narrative review, it is not a meta-analysis.
Why do COVID patients develop VAP?
The risk of developing nosocomial infections in critically ill COVID patients is multifactorial. In terms of extrinsic factors, it has been proposed that a lack of adequate staffing and personal protective equipment (PPE) at the beginning of the pandemic may have led to an increased rate of cross-contamination between patients, leading to higher rates of VAP in COVID patients compared with non-COVID patients [2, 3]. COVID patients are also mechanically ventilated for longer and are more likely to require prone positioning than non-COVID patients. It has been reported in some studies that this group of patients are placed in the prone position twice as frequently as influenza patients [4, 5]. Although prone positioning may increase drainage of oral secretions, it has not been shown to reduce VAP [6]. The addition of immunomodulating agents such as corticosteroids, interleukin-6 (IL-6) antagonists and janus kinase inhibitors [7] may further increase the risk of infection.
The RECOVERY trial demonstrated that corticosteroids decreased the length of mechanical ventilation [8]. Although corticosteroids are sometimes described as a risk factor for VAP, the CoDEX trial displayed a similar reduction in length of mechanical ventilation, with no increase in the rate of VAP [9]. Gragueb-Chatti et al. [10] demonstrated no increase in VAP or bloodstream infection in a multicentre study.
IL-6 antagonists are also postulated to create an immunosuppressive state. Yet, some benefits have been shown for these agents before intubation: they may decrease the need for intubation and decrease mortality. Further research in this area is required [11]. Likewise, janus kinase inhibitors may create an immunosuppressive state, but could also be beneficial in reducing mortality if given in the initial 1–2 weeks of infection. Again, further studies are needed [7]. At present, we can speculate that these drugs may cause immunosuppression and potentially lead to increased rates of VAP.
Grasselli et al. [12] demonstrated that COVID patients on extracorporeal membrane oxygenation (ECMO) had a rate of VAP of 35%. This was related to a longer duration of stay in the ICU and a higher mortality rate. Luyt et al. [13] showed that COVID patients on ECMO had higher rates of VAP compared to influenza patients on ECMO, although the overall rate of bacterial co-infection was higher in the influenza population.
In terms of intrinsic factors, COVID patients have more severe parenchymal damage and poorer lung compliance compared with non-COVID patients, both of which are risk factors for VAP [14]. It is hypothesised that SARS-CoV-2 infection may cause an element of immunoparalysis [15], along with immune dysregulation, resulting in hyperinflammation and issues with lymphoid function [16–18]. One study showed that COVID patients who went on to develop VAP had a detectable change in their lung microbiome several weeks before [19], with a decrease in their antibacterial immune defence. De Pascale et al. [20] found that the lung microbiome in COVID-19 patients who developed Staphylococcus aureus VAP was significantly different from that in non-COVID patients. They found lower bacterial diversity, with S. aureus, Streptococcus anginosus and Olsenella making up the dominant growth. It is theorised that SARS-CoV-2 infection may also cause pulmonary vascular endothelial inflammation and subsequent thrombosis [21–25]. These factors combined create an environment suitable for bacterial growth.
In summary, extrinsic factors include staff shortages, lack of PPE [7], treatment with immunomodulating agents [6, 10, 11] and ECMO [7, 12]. These may account for the increased rate of VAP in critically ill COVID patients compared to non-COVID patients. The effect of steroids is controversial and has been shown in some studies to yield improved outcomes [8, 9]. Intrinsic factors relating to the disease process itself include lung parenchymal damage, poor compliance [13], immune dysregulation [14–18], alterations in the lung microbiome [19] and increased risk of thrombosis [20–24], all of which may play a role in creating a suitable environment for bacterial growth. All risk factors considered, VAP is a serious complication of COVID pneumonitis. It is associated with shock, bacteraemia and polymicrobial infections [26]. Therefore, it still poses challenges to clinicians [27].
Prevalence
A meta-analysis in May 2021 found that the rate of VAP was elevated in COVID patients compared to non-COVID patients [3]. The rate of VAP was 45.4%, with a range of 7.6–86%. These differences in rate of VAP may be attributable to differences in clinical settings, staffing, patient factors (such as reason for ICU admission and disease severity) and the diagnostic criteria for VAP used in each study. The ICU mortality rate was 42.7% in critically ill COVID patients, but this was not necessarily attributable to VAP. The mean ICU length of stay (LOS) was 28.58 days. The authors of the meta-analysis did highlight slight variations in the definition of VAP in the different retrospective studies used, which can pose difficulty when comparing different studies.
Fumagalli et al. [3] described a rate of VAP of ∼50%, with a range of 21–64%. The first episode of VAP was usually detected between days 8 and 12 of invasive ventilation. The mean length of mechanical ventilation was 12–30 days. ICU mortality of COVID patients with VAP was similar to that of non-COVID patients with VAP, at ∼40–55% [28, 29]. This is in keeping with the findings of Fumagalli et al. [3].
Jain et al. [30] described the rate of VAP in COVID patients as 48.15%, with a mortality rate of 51.4%. COVID patients had an overall increased risk of VAP compared to non-COVID patients. Male patients had an increased risk of VAP [30]. Blonz et al. [31] showed a rate of VAP of 48.9%, with a recurrence rate of 19.7%. VAP has been shown to occur late in mechanical ventilation [31–33]. Nseir et al. [29] described an association between VAP and an increased 28-day mortality in COVID patients. Yet, this was not any higher than in patients with influenza or intubated for a non-viral reason.
Challenges of diagnosis
It is important to note that some controversy does exist around the diagnosis of VAP. Sampling methods may vary depending on region [27]. An element of subjectivity regarding diagnosis may also be involved [3]. If a patient's specimen is cultured and fails to grow any microbe, that patient may not be recorded in many studies as having VAP. Should a patient not have any cultures sent owing to other reasons, they too will not be recorded as having VAP. Many of the clinical signs that would indicate VAP are also shared with acute respiratory distress syndrome (ARDS), atelectasis and pulmonary oedema. The administration of steroids or ECMO may mask a fever [2]. The Clinical Pulmonary Infection Score has been proposed to predict VAP. It considers temperature, leukocyte count, tracheal secretions, arterial oxygen tension:inspiratory oxygen fraction ratio, imaging and cultures [34]. However, it is not currently included in the most recent guidelines on treatment of VAP because of the risk of antibiotic overuse [35].
There is conflicting evidence in relation to the use of invasive versus noninvasive diagnostic procedures. Invasive diagnostic strategies, such as bronchoalveolar lavage (BAL), have been shown to reduce mortality, identify organ failure earlier and reduce the overuse of antibiotics when compared to noninvasive strategies [36]. Yet, no significant differences in patient outcomes were shown when invasive versus noninvasive diagnostic strategies were compared in a meta-analysis in 2014 [37]. It is important to note that invasive or distal strategies include BAL, protected specimen brush and lung biopsy. Blind mini-BAL is not always guaranteed to obtain a distal sample and is classified as a noninvasive strategy [35].
In critically ill COVID patients, performing BAL poses its own risks. This cohort of patients may display poor oxygenation and poor compliance due to ARDS. There is also a risk of viral transmission. One study showed a decrease in the use of BAL from 60% to 25% due to the pandemic [38]. Despite the aforementioned risks associated with invasive sampling, we would recommend the use of invasive techniques when possible. It is important to keep both patient and staff safety in mind. This will enable de-escalation of antibiotics as soon as possible, decreasing overuse.
C-reactive protein (CRP), procalcitonin and soluble triggering receptor expressed on myeloid cells (sTREM-1) are some of the biomarkers that may be useful in the diagnosis of VAP in all patients. Further studies are required [39–42]. Clinical assessment is still regarded as paramount. The use of routine monitoring of a specific biomarker is not recommended [43, 44].
In patients receiving an IL-6 inhibitor, CRP levels may not be an accurate marker. IL-6 is involved in the stimulation of CRP synthesis from hepatocytes [45, 46]. Initial studies demonstrated a low procalcitonin level in patients with SARS-CoV-2 infection alone [47, 48]; however, elevated procalcitonin has also been shown in severe SARS-CoV-2 infection [49]. Viral infection may also interfere with interferon-γ release, and this may cause an inaccurate procalcitonin level [50]. Rouzé et al. [51] demonstrated slightly elevated procalcitonin in patients with bacterial co-infection versus patients without, although not as elevated as in influenza patients with co-infection. In diagnosis, procalcitonin has been described as a promising tool, requiring further evaluation [52, 53].
In summary, biomarkers such as CRP and procalcitonin show promise but require further research. Our recommendations are to use these biomarkers as adjuncts to diagnosis. Clinical context is essential, and they should not be used in place of clinical acumen.
Aetiology
Bacterial
A meta-analysis by Ippolito et al. [4] demonstrated that the main bacteria grown in VAP mostly comprised the gram-negative bacteria Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp. and Escherichia coli, along with the gram-positive bacteria S. aureus and Enterococcus faecium. This is in keeping with previous descriptions [3]. Fumagalli et al. [3] described how >50% of bacteria grown were gram negative. Blonz et al. [31] demonstrated that Enterobacteriae accounted for half of the microbiological growth and Pseudomonas accounted for 15.1%. Papazian et al. [35] described how the microorganisms responsible for VAP can vary depending on multiple factors. These include the length of hospital and ICU stay, length of mechanical ventilation, local bacterial strains and exposure to antimicrobial drugs. The bacteria that are usually isolated may not be related to intubation; they are related to the severity of underlying disease [3]. Increased use of empirical antibiotics due to the COVID-19 pandemic poses a threat of increased multidrug-resistant organisms (MDROs) in the future, and we will discuss this later in the review [54].
COVID-19-associated invasive pulmonary aspergillosis
In comparison to bacteria, Aspergillus is rarely the causative agent of VAP in non-COVID patients, except for in patients undergoing mechanical ventilation for influenza, or in the immunocompromised. Rouzé et al. [55] demonstrated a lower incidence of invasive pulmonary aspergillosis (IPA) in COVID patients than in influenza patients (4.1% versus 10.2%, respectively). This may be due to the increased proportion of immunosuppressed patients recorded in the influenza group, although this was adjusted for. BAL was performed less frequently in the COVID group owing to the risk of viral transmission, which may have led to under-recognition of aspergillosis. Finally, the authors concluded that the mechanism of entry into the lower respiratory tract and pulmonary lesions related to SARS-CoV-2 and influenza are different. This may account for the different rates of IPA [55]. Aspergillus infection may be under-diagnosed because of delays in diagnosis or a lack of recognition [56]. IPA has become more prevalent as a cause of VAP in COVID patients versus non-COVID patients in general [3]. Fumagalli et al. [3] reported an incidence of COVID-19-associated IPA of 4–30%. This is higher than in the non-COVID population, but further data are required. One multicentre study in the UK reported that aspergillosis may be under-diagnosed in critically ill non-COVID non-neutropenic patients. Up to 20% of VAP may in fact be IPA. The authors of that study advised clinicians to practise a high level of suspicion, and to use galactomannan whenever these patients undergo BAL [57]. They also advised clinicians to acquire distal samples for culture, along with consecutive serum galactomannan indices. Galactomannan from BAL fluid has shown promising results in the early identification and exclusion of COVID-19-associated IPA, but it must currently be used as an adjunct to the clinical picture. Galactomannan from endotracheal aspirate samples is yet to be validated [58]. β-D-glucan has been shown to support the diagnosis of COVID-19-associated IPA [59–61]. Again, this must be used in conjunction with the clinical context. Two or more positive results have a greater diagnostic ability. Real-time PCR for Aspergillus DNA supports the diagnosis [59, 60]. A lateral flow device provides an incredibly quick method of detection of the Aspergillus antigen [61]. Increased length of mechanical ventilation and steroid use increase the risk of Aspergillus infection [62]. To treat IPA, current guidelines recommend the use of a triazole (voriconazole or isavuconazole) initially [29, 63]. Diagnosis and treatment is outlined in figure 1 [61]. A phase 4 trial looking at the use of prophylactic posaconazole for influenza patients is ongoing, although no results are available yet (https://clinicaltrials.gov/ct2/show/NCT03378479). Three other antifungals are currently undergoing trials: ibrexafungerp (https://clinicaltrials.gov/ct2/show/NCT03059992), olorofim (https://clinicaltrials.gov/ct2/show/NCT03583164) and fosmanogepix (https://clinicaltrials.gov/ct2/show/NCT04240886). Hopefully, these new medications can provide other treatment options in the future. It is important to note that antifungal resistance (triazole resistance) is increasing. Therefore, techniques to identify these resistant strains may be crucial for the choice of antifungal treatment, and for epidemiological data [29]. Candida has still not been identified as a VAP-causing agent at this point [64].
Viral
Viruses such as respiratory syncytial virus and influenza, among others, can cause VAP [65, 66]. Herpes simplex virus (HSV) and cytomegalovirus can cause reactivation pneumonia in immunocompromised patients [67]. Some studies have shown a benefit to treating viral reactivations with antivirals but further research is required [36]. Meyer et al. [68] showed that HSV reactivation in COVID patients is associated with increased 60-day mortality. Of the 153 critically ill COVID patients included in the study, they found a reactivation rate of 26.1%.
Other agents
No reports of VAP caused by atypical bacteria were identified in our search. It appears that atypical bacteria are not a frequent cause of co-infection in COVID patients, and even less so a cause of VAP. Streptococcus pneumoniae is rarely seen. Yet, they should still be considered within the clinical context of each patient [52–54]. Tuberculosis (TB) is not a common cause of VAP and is more likely to have been present before SARS-CoV-2 infection. TB patients are at higher risk of COVID infection, with a higher mortality rate [69]. Our search found no cases of VAP caused by non-tuberculous mycobacteria. However, two cases of co-infection with mycobacteria in COVID patients were described in the literature (M. simiae [70] and M. abscessus [71]).
Prevention and infection control
From a nursing standpoint, good preventative measures are crucial in all intubated patients (COVID and non-COVID) [72]. Elevation of the head of the bed, draining of subglottic secretions and maintenance of endotracheal cuff pressure all decrease the risk of aspiration. Avoiding prolonged mechanical ventilation can be achieved by appropriate weaning. Daily interrupted sedation has been shown to decrease rates of VAP [73]. It is thought that this is secondary to an improved respiratory function and gag reflex. Daily evaluation for extubation should also be carried out. An effort should be made to reduce the pathogen load. Different techniques such as regular tooth brushing and chlorhexidine mouthwash have also been shown to decrease rates of VAP [74]. Early enteral feeding within 48 h can reduce the rate of translocation of intestinal bacteria to the lungs [75]. Conversely, routine circuit changes have been shown to increase rates of VAP [76]. Suction of the endotracheal tube should be performed only when necessary and with good technique, yet subglottic suctioning has been described as under-utilised and is recommended in COVID patients receiving mechanical ventilation [77]. Two studies based in the non-intensive care setting have shown decreased rates of VAP with brief intubations during theatre. Nam et al. [78] reported a 600% decrease in postoperative VAP in cardiac patients who underwent routine subglottic suctioning and Yuzkat and Demir [79] showed decreased rates of VAP post rhinoplasty surgery. We could not find any literature comparing these preventative measures on the development of VAP between COVID and non-COVID patients. Sakano et al. [80] advise that the most up-to-date evidence must continue to be incorporated into ICU care bundles (as discussed in this paragraph). They make the solid point that the best way to avoid VAP is to avoid intubation in the first place.
The above-mentioned practices can be incorporated into care bundles aimed specifically at reducing rates of VAP [81]. These practices can be applied to all ventilated patients. In terms of nursing ventilated COVID patients specifically, the following recommendations have been made: oral intubation is preferred over nasal, a closed suctioning system should be used to drain and discard condensation, head of bed elevation should be in place, a new circuit should be used with each patient and only changed when necessary, and heat and moisture exchanger filters should only be changed every 5–7 days or when soiled [82]. Owing to the challenges mentioned previously regarding the diagnosis of VAP, one cannot say with complete certainty if these preventative measures reduce the rate of VAP. The definition of VAP in different studies may vary [83].
Adequate staffing has also been shown to be essential. The nurse-to-patient ratio has been suggested as a good indicator for the level of staffing. This not only helps to decrease pathogen spread, but also benefits adequate diagnosis and treatment of VAP [84, 85]. It is important to note that many ICUs around the world expanded outside their original setting because of the sudden high demand for ICU beds. Therefore, many critically ill patients received care outside of ICU. These patients showed elevated mortality [86].
Infection control plays a key role when treating COVID patients. We would advise specific antimicrobial surveillance studies for the ICU [55, 87]. Diagnostic tests should be carried out when infection is suspected, not pre-emptively. Patients should be cared for in separate rooms [81]. It has been advised that healthcare workers wear full PPE, including visor and N95 facemasks, when caring for patients. All healthcare staff involved should be vaccinated against SARS-CoV-2. At present, it is not advised to routinely test staff for SARS-CoV-2 infection. Basic hand hygiene, infection control surveillance, disinfection of clinical areas and separation of waste have all been advised [81]. Antimicrobial stewardship remains a key feature, as with non-COVID patients. The aim is to not only prevent viral transmission of COVID, but also reduce the spread of other pathogens and MDROs [88].
Treatment
The initial empirical cover advised for VAP is summarised in figure 2 [89–91].
Studies have reported a mean ICU mortality for COVID patients who develop VAP of 42.7% [2], but the exact attributable mortality is unknown. It is important to treat each individual patient within their own clinical context.
The efficacy and appropriateness of novel antibiotics against resistant gram-negative bacteria has been summarised by Garduno et al. [92].
The efficacy of nebulised antibiotics has not yet been demonstrated [93, 94]. Many patients have concomitant bloodstream infections for which nebulised antibiotics alone would be inappropriate [95]. Apart from colistin, no significant increase in efficacy has been shown when nebulised antibiotics are used as an adjunct to the intravenous route [54, 96–98].
Stewardship
Risk factors for MDROs include previous colonisation, ARDS occurring before VAP, septic shock and acute renal replacement therapy before VAP [4]. Increased use of empirical antibiotics owing to the COVID-19 pandemic poses a threat of increased MDROs in the future [87]. Enterobacteriaceae resistant to cephalosporins have become more common, with resistance due to extended-spectrum β-lactamase and AmpC B-lactamase expression [99]. Carbapenemase expression is also worrying. P. aeruginosa strains that are multidrug resistant are also becoming more frequently detected [100]. 50–67% of A. baumannii strains grown from VAP are carbapenem resistant [101]. Critically ill COVID patients are at increased risk of MDROs, and this can significantly influence outcome [102]. One study performed in a single centre found that ∼77% of K. pneumoniae cultured from COVID patients in the ICU demonstrated multidrug resistance [103].
Some guidelines do not recommend administering antibiotics to patients who have a negative culture and are clinically stable [4]. Exposing patients to fewer unnecessary antibiotics should decrease the risk of bacterial imbalance, which leads to infections such as Clostridium difficile. It should also decrease the development of MDROs. However, it is ultimately the clinician's decision whether the patient is at risk of deterioration, and if antibiotics should be commenced [4]. Administering antibiotics before sampling can yield a false-negative result. Papazian et al. [35] recommend re-evaluating every 48–72 h, using the clinical course to decide when to stop antibiotics. This is in relation to VAP in all patients [35]. They also describe the use of decreasing procalcitonin to stop antibiotics. A procalcitonin concentration <0.5 ng·mL−1 or that has reduced by 80% from its peak at 48–72 h may indicate that it is appropriate to stop antibiotics [104, 105], but clinical judgement should still be used. As previously discussed, we would not recommend reliance on procalcitonin alone, and further research is required in this area. At present, it takes anywhere from 24 h to 48 h to culture bacteria. Broad-spectrum empirical antibiotics are required during this time. Ideally, patients should only receive broad-spectrum antibiotics for as short a duration as possible. Therapy should be targeted based on cultures, which should decrease the growth of MDROs. Methods such as PCR can identify bacteria and resistant strains quicker but must be requested for specific pathogens. One example is mecA to detect methicillin-resistant S. aureus [106]. There is a new diagnostic tool called the Unyvero system that can identify the most common causative agents of VAP (20 bacteria and one fungus). It can also detect 19 markers of resistance. Results are available within 4–5 h. However, at present, Unyvero may over-detect; it can detect commensals, non-viable bacteria and pathogenic bacteria that have not reached pathogenic thresholds, which may lead to the overuse of antibiotics. Although this technique does require further refinement, it does pose a potential improvement in VAP diagnosis in the future [107–110].
Antibiotic overtreatment could be a risk factor for developing VAP in COVID patients. An imbalance in the body's natural flora can occur as a result. In the early days of the pandemic, azithromycin was thought to have some antiviral properties against SARS-CoV-2. This has now been disproven and azithromycin is not recommended as empirical treatment anymore. Despite this, Blonz et al. [31] did find that the risk of polymicrobial VAP was reduced with the initiation of empirical antibiotics. At present, empirical antibiotics are not routinely recommended for COVID patients without any evidence of bacterial infection because this may lead to overuse, along with the development of MDROs [111]. Combination therapy is advised when treating VAP, except for patients in the early stages of VAP or without risk of MDROs. Therapy should be targeted based on cultures and is usually recommended for 7 days [35]. Karolyi et al. [112] performed a study that showed how the results of a multiplex PCR were consistent with microbiological cultures. This could provide earlier bacterial identification in the future. They concluded that diagnosis could be made more easily if both techniques are used together.
Weaning and re-infection
Unsuccessful weaning has been associated with poorer outcomes. Elevated peak plateau pressures may increase the risk of unsuccessful weaning, whereas higher compliance and lower driving pressures may reduce the risk. Positive end expiratory pressure, partial pressure of carbon dioxide and arterial oxygen tension:inspiratory oxygen fraction ratio appear to have no significant bearing on whether a patient is weaned successfully or not [113]. Protective mechanical ventilation is advised [114]. One article showed that patients extubated within 2 weeks had no pathogenic growth; however, these patients may only have been extubated because they did not develop VAP [115]. Tracheostomy placement is safe and beneficial in this group of patients [116–119], although a higher rate of tracheomalacia has been reported (5%) [120]. Tracheostomy has been shown to improve ICU capacity [121]. Although no difference has been shown between early and late tracheostomy insertion in terms of mortality [122], earlier tracheostomy placement has better overall outcomes [123]. There may be a benefit in preserving muscle mass [124].
Although Blonz et al. [31] showed a recurrence rate of 19.7%, another study reported re-infection rates of 43% in critically ill COVID patients, which did influence prognosis. The authors suggest that hospital overburden at the start of the pandemic could have been responsible for this [125]. Immune dysregulation could also be a factor [126]. MDROs are frequently seen in re-infection. Re-infection is associated with length of mechanical ventilation and ICU LOS. Early diagnosis plays a key role in identifying MDROs early, commencing adequate treatment and improving outcomes [127].
Long-term issues
There is a high mortality rate in critically ill COVID patients 3 months post hospital discharge [128], with ongoing symptoms found in two thirds of patients discharged and 10% of these requiring home oxygen. However, hospital readmission rates in these patients were still low. Persistent symptoms were associated with the following independent risk factors: female gender, ICU LOS, ICU-acquired pneumonia and ARDS. Of these, ICU-acquired pneumonia prevention could yield a potential reduction in mortality post discharge [91].
Conclusion
The COVID-19 pandemic has tested ICUs globally. For several reasons, COVID patients are at high risk of developing VAP. Although the diagnosis of VAP remains controversial, and can vary from study to study, an elevated incidence has been shown in COVID patients. A review of major studies suggested a rate of VAP between 7.6% and 86% [3]. The ICU mortality rate was 42.7% (not necessarily attributable to VAP) [1]. The mean ICU LOS was 28.58 days. Gram-negative bacteria such as Pseudomonas (15.1%), along with the gram-positive S. aureus, were the most common organisms grown [3]. COVID-19-associated pulmonary aspergillosis was reported in 4–30% [2]. Viruses were even less common. Atypical bacteria and TB were not reported as a cause of VAP. Preventative measures can be implemented through care bundles, and this may lead to a reduction in VAP. Treatment is recommended to begin with a broad empirical cover but this should be targeted based on microbial growth as soon as possible. MDROs are already increasing in frequency, and antibiotic stewardship will continue to play an essential role. Biomarkers such as procalcitonin show potential, but still require further evaluation. Drugs commonly used in the treatment of COVID patients, such as dexamethasone, tocilizumab and janus kinase inhibitors, considerably reduce CRP and procalcitonin. This causes another challenge in diagnosis [47]. New methods of early identification of microbes along with certain resistance patterns could result in improved diagnosis and treatment in the future. Ongoing trials of new medications and techniques are yet to display any positive findings. Although our knowledge of this disease process is ever expanding, we still hold a pessimistic view for this group of patients. We would recommend the use of invasive techniques when possible. This will enable de-escalation of antibiotics as soon as possible, decreasing overuse. It is important to diagnose other possible causes of VAP, e.g. COVID-19-associated IPA and cytomegalovirus. Other diagnostic tests such as galactomannan and β-D-glucan should also be used.
Footnotes
Provenance: Commissioned article, peer reviewed.
Conflict of interest: None declared.
- Received January 25, 2022.
- Accepted April 24, 2022.
- Copyright ©The authors 2022
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