TY - JOUR T1 - Valproic acid improves second-line regimen of small cell lung carcinoma in preclinical models JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00028-2015 VL - 1 IS - 2 SP - 00028-2015 AU - Roland Hubaux AU - Fabian Vandermeers AU - Jean-Philippe Cosse AU - Cecilia Crisanti AU - Veena Kapoor AU - Steven M. Albelda AU - CĂ©line Mascaux AU - Philippe Delvenne AU - Pascale Hubert AU - Luc Willems Y1 - 2015/10/01 UR - http://openres.ersjournals.com/content/1/2/00028-2015.abstract N2 - With 5-year survival rates below 5%, small cell lung carcinoma (SCLC) has very poor prognosis and requires improved therapies. Despite an excellent overall response to first-line therapy, relapses are frequent and further treatments are disappointing. The goal of the study was to improve second-line therapy of SCLC.The effect of chemotherapeutic agents was evaluated in cell lines (apoptosis, reactive oxygen species, and RNA and protein expression) and in mouse models (tumour development).We demonstrate here that valproic acid, a histone deacetylase inhibitor, improves the efficacy of a second-line regimen (vindesine, doxorubicin and cyclophosphamide) in SCLC cells and in mouse models.Transcriptomic profiling integrating microRNA and mRNA data identifies key signalling pathways in the response of SCLC cells to valproic acid, opening new prospects for improved therapies.Valproic acid improves second-line regimen of SCLC response in preclinical models http://ow.ly/Rsyd8 ER -