TY - JOUR T1 - The role of complement activation in COPD exacerbation recovery JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00027-2016 VL - 2 IS - 4 SP - 00027-2016 AU - John-Paul Westwood AU - Alexander J. Mackay AU - Gavin Donaldson AU - Samuel J. Machin AU - Jadwiga A. Wedzicha AU - Marie Scully Y1 - 2016/10/01 UR - http://openres.ersjournals.com/content/2/4/00027-2016.abstract N2 - Complement anaphylatoxins (C3a, C5a) are potent inflammatory mediators, implicated in the exaggerated inflammatory response seen in chronic obstructive pulmonary disease (COPD) [1]. COPD patients have decreased levels of serum C3 and C4 [2, 3], and higher levels of sputum C3a and C5a, than healthy volunteers [4]. Both sputum and serum C5a levels climb during acute exacerbations [1, 5]. Serum C5a during COPD exacerbations has been positively correlated with C-reactive protein (CRP) and negatively correlated with percentage predicted forced expiratory volume in 1 s (FEV1 % pred) [5].Rise in sputum complement (C3a, C5a) levels during COPD exacerbation is associated with recovery time http://ow.ly/ZaPj303xxPfConception and design: J.-P. Westwood, A.J. Mackay, M. Scully; analysis and interpretation: J.-P. Westwood, A.J. Mackay, J.A. Wedzicha, S.J. Machin, G. Donaldson, M. Scully; drafting the manuscript for important intellectual content: J.-P. Westwood, A.J. Mackay, J.A. Wedzicha, M. Scully. ER -