TY - JOUR T1 - Comprehensive evaluation of airway involvement in pulmonary sarcoidosis JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00105-2016 VL - 3 IS - 1 SP - 00105-2016 AU - Kiminobu Tanizawa AU - Tomohiro Handa AU - Sonoko Nagai AU - Akio Niimi AU - Tsuyoshi Oguma AU - Takeshi Kubo AU - Yutaka Ito AU - Kensaku Aihara AU - Kohei Ikezoe AU - Hisako Matsumoto AU - Toyohiro Hirai AU - Kazuo Chin AU - Michiaki Mishima Y1 - 2017/01/01 UR - http://openres.ersjournals.com/content/3/1/00105-2016.abstract N2 - Sarcoidosis most commonly affects the thoracic lymph nodes, lung parenchyma and airway in nearly two-thirds of patients [1]. We previously reported that airflow limitation in Japanese outpatients was associated with radiographic stage IV disease, older age, smoking and bronchovascular bundle thickening on high-resolution computed tomography (HRCT) [2]. Airway hyperresponsiveness (AHR) can be another potential predisposing factor of airflow limitation [1, 3]. Impulse oscillometry (IOS) is an effort-independent and noninvasive method of assessing respiratory physiology and may detect more subtle changes than spirometry [4]. Thus, a multidisciplinary approach including AHR provocation test and IOS may provide novel insights into airway involvement of sarcoidosis compared to classical spirometric assessments. We conducted a prospective observational study to comprehensively evaluate airway involvement in patients with pulmonary sarcoidosis and investigate the impacts of various aspects of airway involvement on the long-term outcome. This study was approved by the Ethics Committee of Kyoto University (Kyoto, University; institutional board number E-530), with all subjects granting written informed consent.IOS can predict airway hyperresponsiveness and long-term outcome in patients with pulmonary sarcoidosis http://ow.ly/bkQH307VD4mWe appreciate M. Jinnai, K. Otsuka, T. Takeda, H. Nakaji, T. Tajiri, H. Inoue, T. Iwata, T. Nagasaki and Y. Kanemitsu (Dept of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan) for the measurement of FeNO and T. Izumi (Kyoto Central Clinic, Clinical Research Center, Kyoto, Japan) for academic advice. We also thank T. Toki, N. Kimura and S. Tamura (Dept of Respiratory Care and Sleep Control Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan) for help with manuscript preparation. ER -