TY - JOUR T1 - Effects of a weight-loss Mediterranean lifestyle intervention on obstructive sleep apnoea: preliminary results of a randomised controlled clinical trial JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.sleepandbreathing-2017.P33 VL - 3 IS - suppl 1 SP - P33 AU - Kallirroi Labrou AU - Michael Georgoulis AU - Lazaros Paraskevopoulos AU - Ioanna Kechribari AU - Emmanuel Vagiakis AU - Nikos Yiannakouris AU - Meropi Kontogianni Y1 - 2017/04/01 UR - http://openres.ersjournals.com/content/3/suppl_1/P33.abstract N2 - Background Continuous positive airway pressure (CPAP) is the first-line treatment for obstructive sleep apnea (OSA); however, weight loss through lifestyle changes is also an important therapeutic choice, especially for overweight patients. Aims and objectives: To explore whether a weight-loss Mediterranean lifestyle intervention (MLI) combined with CPAP is superior in the management of OSA, compared to standard care. Methods: 36 overweight patients (77.8% men, age: 50±10y), with polysomnography-diagnosed moderate-to-severe OSA and treated with CPAP, were randomized to either a standard care group (SCG, n=18) or a MLI group (MLIG, n=18). Patients in SCG received CPAP and written general lifestyle advice for weight loss, while those in MLIG participated in an intensive 6-month weight loss MLI, in addition to CPAP treatment. Intention-to-treat analysis and repeated measures ANOVA were performed. Results: The two groups did not differ in lifestyle or clinical parameters at baseline. Following intervention, the MILG showed greater reduction in BMI (P<0.001). Compared to the SCG, patients in the MILG exhibited greater improvements in the apnea-hypopnea index (57±36 to 31±24 events/h vs 56±28 to 53±25 events/h, P<0.001), mean haemoglobin saturation decrease (7.1±3.2 to 5.1±3.6% vs 6.4±2.8 to 6.1±1.2%, P<0.001) and physical health (SF-36: 43±10 to 52±10 vs 37±8 to 40±10, P=0.04). Daytime sleepiness and degree of insomnia improved similarly in both groups. Conclusions: A weight loss MLI combined with CPAP offers additional improvements in OSA severity, compared to standard care. ER -