RT Journal Article
SR Electronic
T1 Neck circumference is the best anthropometric marker for sleep apnoea and cardiometabolic risk in class II or III obese women
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP P62
DO 10.1183/23120541.sleepandbreathing-2017.P62
VO 3
IS suppl 1
A1 Anne-Laure Borel
A1 Sandrine Coumes
A1 Nelly Wion
A1 Fabian Reche
A1 Catherine Arvieux
A1 Jean-Louis Pépin
YR 2017
UL http://openres.ersjournals.com/content/3/suppl_1/P62.abstract
AB Background Adiposity repartition is appreciated by waist and hip girths. These measures are technically hard to collect in severely obese women. In addition, waist and hip girths increase along with body mass index (BMI) that prevents defining thresholds associated with increased cardiometabolic risk (CMR).Aims and objectives to assess which of waist, hip or neck girth is the best anthropometric marker of visceral adiposity related CMR. Class II and III obese women (n=270), aged 43 years-old [IQR 34-52], BMI 44.3 kg/m2 [IQR 41.0-48.3] were included in the Severe Obesity Outcome Network (SOON) cohort. Anthropometric and metabolic profiles were collected. Waist, hip and neck girths were compared for their respective association with CMR markers.Results 28% percent of women presented with type 2 diabetes, 28% with hypertension, 31% with sleep apnea syndrome (SAS). Waist and neck circumference were positively correlated with HbA1c, fasting glucose, 120 min-OGTT glucose, HOMA-IR, gamma-glutamyl transferase (GGT), triglycerides, apnea-hypopnea index (p<0;01). Hip circumference was negatively correlated with HbA1c, HOMA-IR, ALAT and ASAT (p<0.01). In multiple logistic regressions, neck circumference (dichotomized at the median 40.5 cm) was associated with severe SAS (OR 2.23 (1.22; 4.13)), hypertension (OR 2.52 (1.36; 4.74)), GGT (OR 4.33 (1.81; 1.66).Conclusion Neck circumference is easy to measure in clinical routine in obese women. It is associated with CMR markers, as is waist circumference. A neck circumference above 40.5cm is associated with sleep apnea, hypertension, and steatohepatitis and could be used as threshold to define a high CMR in class II and III obese women.