%0 Journal Article %A Nesreen Morsy %A Lucy Suliman %A Nisreen Omar %A Ahmed El-sebaie %A Amal Fathy %T Modelling obstructive sleep apnoea susceptibility using noninvasive inflammatory biomarkers %D 2017 %R 10.1183/23120541.sleepandbreathing-2017.P16 %J ERJ Open Research %P P16 %V 3 %N suppl 1 %X Introduction Obstructive sleep apnea (OSA) is one of the systemic inflammatory diseases but inflammatory markers are not widely used in all sleep clinics.Aims Study some inflammatory markers in the serum and exhaled breath to explore the potential relationships between them and OSA.Patients and methods The study included 61 participants, 44 newly diagnosed OSA and 17 healthy control. All participants were non-smokers, free of any inflammatory disorders or use of regular medication, or had respiratory tract infection 2 weeks prior to sampling. Cases were recruited from pulmonary medicine OPC. They had full night PSG then at next morning, fractional exhaled nitric oxide (FeNO) was measured, blood sample were collected for measuring of high sensitivity C- reactive protein (HS-CRP) and Erythrocyte sedimentation rate (ESR) (1st&2ndh).Results A significant differences were founded of Basal and minimal oxygen saturation, arousal index, FeNO, ESR (1st, 2ndhour), HS-CRP with p value ≤0.001 for all in comparison of cases and controls. The cases group were sub classified into sever (AHI≥30) (n=34) and non-sever (AHI ˂ 30) (n=10). A significant differences of basal, minimal oxygen saturation and arousal index (p= 0.008, 0.04, 0.02) were found, But no significant differences as regard age, BMI, FeNO, ESR (1st, 2ndhour), HS-CRP with p value (0.8, 0.4, 0.6, 0.7, 0.2, 0.4).The predicted cut off point of FeNO, HS-CRP, ESR (1st, 2ndhrs) which can be used in OSA diagnosis are (8,5.5,6.5,13.5) with sensitivity of (0.88,0.95,0.83,0.93) and specificity of (0.77,0.88,0.63,0.63).Conclusion FeNO, ESR (1st, 2ndhour) and HS-CRP may be used as simple tests to predict OSA diagnosis with cut off points. %U