PT - JOURNAL ARTICLE AU - Helen Pringleton AU - Steven Powell AU - Anne-Marie Ebdon TI - Effect of adenotonsillectomy on OSA symptoms in children with Down's syndrome AID - 10.1183/23120541.sleepandbreathing-2017.P52 DP - 2017 Apr 01 TA - ERJ Open Research PG - P52 VI - 3 IP - suppl 1 4099 - http://openres.ersjournals.com/content/3/suppl_1/P52.short 4100 - http://openres.ersjournals.com/content/3/suppl_1/P52.full SO - erjor2017 Apr 01; 3 AB - Background Children with Down's syndrome have a high rate of obstructive sleep apnoea (OSA). Previous studies have shown that adenotonsillectomy is effective in improving OSA but with differing success rates.Objective To evaluate the effectiveness of adenotonsillectomy in improving OSA symptoms in children with Down's syndrome within our population.Methods The medical records of 32 children with Down's syndrome who underwent tonsillectomy or adenotonsillectomy for OSA between 1stJanuary 2010 and 1stMay 2016 were reviewed retrospectively. Parameters reviewed included age, height and weight at time of surgery and pre- and post-surgery data relating to oximetry performed, reported snoring and daytime somnolence and frequency of lower respiratory tract infections.Results 15/32 children were male. The median age was 4.8y (interquartile range 3.1, 9.6). All children had pre-operative snoring with post-operatively improvement in 25/32 (78.1%) of children. Oximetry data was available both pre- and post-operatively in only 12/32 but all showed improvement. 21/32 children had congenital heart disease (CHD). Of the 7/32 children who didn't have symptomatic improvement, 4 (57%) were male. The median age was 4.6y (3.8, 9.2). One child was obese with a weight >98thcentile. Four had CHD. Two commenced mask ventilation for their OSA due to ongoing clinical symptoms post-operatively.Conclusions Over 75% of children had symptomatic improvement of their OSA following surgical intervention. Adenotonsillectomy is an important treatment option for OSA in children with Down's syndrome.