RT Journal Article SR Electronic T1 Effect of a 9-month supervised physical activity programme on moderate obstructive sleep apnoea: a randomised controlled trial JF ERJ Open Research JO erjor FD European Respiratory Society SP P23 DO 10.1183/23120541.sleepandbreathing-2017.P23 VO 3 IS suppl 1 A1 Mathieu Berger A1 David Hupin A1 Frédéric Costes A1 Jérémy Raffin A1 Stéphanie Chomette-Ballereau A1 Pierre Labeix A1 Mathilde Donnat A1 Emilia Sforza A1 Jean-Claude Barthélémy A1 Frédéric Roche YR 2017 UL http://openres.ersjournals.com/content/3/suppl_1/P23.abstract AB Introduction Obstructive sleep apnea (OSA), highly prevalent in the general population, determines a sharp increased in cardiovascular morbi-mortality. While CPAP remains the gold standard treatment, long-term compliance is poor.Aim To evaluate the benefits of a 9-month supervised physical activity program (NeuroGyV program, FFEPGV) on moderate OSA.Method From a group of 63 patients aged 40-80 years with moderate OSA (15≤Apnea Hypopnea Index (AHI)≤30), 30 were randomized in an exercise group including 3x1 hour of physical activity per week (nordic walking, aquagym and gymnastic at their metabolic threshold); 33 participants included in a control group received standard diet and physical activity advices. OSA severity was assessed with ambulatory polygraphy, and a metabolic exercise stress test was systematically performed, before and after 9 months of study.Results At follow-up, exercise group shows a significant 21.6% AHI reduction (from 21.3±5.1 to 16.7±7.5; p< 0.01) compared to a 6.0% rise in control group (from 21.5±4.5 to 22.8±11.4; ns). Exercise group also shows a significant drop in subjective sleepiness (Epworth score scale: from 9.1±4.2 to 6.0±3.8; p<0.001) while there was no significant difference in control group (from 7.6±4.2 to 7.0±4.6). In the whole population, delta AHI is negatively correlated with delta VO2max(r= -0.36; p<0.01) and positively correlated with delta BMI (r= 0.28; p<0.05).Conclusion Community supervised regular physical activity is effective, reducing significantly AHI, and could thus be considered as an effective treatment in moderate OSA.