TY - JOUR T1 - Prescription of automatic bilevel ventilation (AutoBI) in sleep-disordered breathing: analysis according to diagnosis and occurrence of comorbidities JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.sleepandbreathing-2017.P21 VL - 3 IS - suppl 1 SP - P21 AU - PierPaolo Baiamonte AU - Claudia Irene Gruttad'auria AU - Emilia Mazzuca AU - Alessandra Castrogiovanni AU - Maria Rosaria Bonsignore Y1 - 2017/04/01 UR - http://openres.ersjournals.com/content/3/suppl_1/P21.abstract N2 - CPAP is the first-choice treatment for obstructive sleep-disordered breathing (O-SDB), while the criteria to prescribe AutoBI are undefined. Trials of AutoBI ventilation in patients (pts) treated for O-SDB from January 2015 to October 2016 (64 out of 242 titrations) were reviewed to assess: a) the clinical characteristics of these pts, b) the reason to shift from CPAP to AutoBI, c) the compliance to prescribed treatment. AutoBI was used in cases of intolerance to high therapeutic CPAP levels (n=21) or incomplete resolution of SDB on CPAP (n=43). The Table reports the differences between CPAP or AutoBI pts CPAP View this table:SDB diagnosis was: 82% OSA, 18% OSA-COPD Overlap in the CPAP group; 39% OSA, 28% OSA-COPD Overlap and 33% OHS in the AutoBI group (p<0.0001). The mean number of comorbidities was higher in Overlap than in OSA or OHS pts(2.67 vs 1.98 and 1.95, respectively, p=0.0003). Mean ventilator use (data available in 70 pts, 34 CPAP, 36 AutoBI) for an average treatment duration of 8 months, was: 5.5±2.2 h/day in AutoBI, and 4.4±2.1 h/day in CPAP groups (p=0.04).In conclusion, AutoBi can be considered an effective and well-tolerated treatment in pts with obstructive SDB, especially in cases with severe obesity, nocturnal hypoventilation, or needing high therapeutic pressures. ER -