TY - JOUR T1 - A U-shaped relationship between fasting plasma glucose and severity of sleep apnoea JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.sleepandbreathing-2017.P96 VL - 3 IS - suppl 1 SP - P96 AU - Georgia Trakada AU - Angeliki Konsta AU - Lemonia Velentza AU - Asimina Mitrakou Y1 - 2017/04/01 UR - http://openres.ersjournals.com/content/3/suppl_1/P96.abstract N2 - Introduction Current evidence supports an association between Obstructive Sleep Apnea Syndrome (OSAS) and insulin resistance and type 2 diabetes mellitus (DM 2). The relation between glycemic profile and severity of OSAS, in nondiabetic patients, is complex and still remains poorly understood.Aim To examine the potential correlation between sleep characteristics and glucose metabolism in nondiabetic patients, with OSAS.Materials and Methods Included were one hundred and fifty seven (157, 104 men and 53 women), with mean age 46.63±10.45years old and mean Body Mass Index (BMI) 31.47±5.8kg/m2, nondiabetic patients, recently diagnosed with OSAS, by full polysomnography. Patients were subdivided into four groups, according to their fasting plasma glucose (FPG) levels: group I: ≤75mg/dl (n=44), group II: 76-86mg/dl (n=37), group III: 87-96mg/dl (n=33) and group IV: ≥97mg/dl (n=43).Results Both, group I, with the lowest FPG and group IV, with the highest FPG were strongly associated with apnea-hypopnea index (AHI) (p=0.02), a widely accepted marker of the severity of OSAS, and with percentage of sleep time with saturation of hemoglobin with oxygen as measured by pulse oximetry (SpO2)<90% (t<90%), (p=0.041).Conclusions In conclusion, the severity of OSAS among nondiabetic patients correlates in a u-shaped relation with FPG. A compensatory, early rise in insulin secretion to maintain normal to low FPG could be an underlying mechanism that promotes the future development of DM 2, in OSAS. More studies are needed to assess whether early diagnosis and treatment of OSAS may reverse insulin resistance and prevent progress to diabetes AHI and fasting glucose ER -