TY - JOUR T1 - Lung function in patients with obstructive sleep apnoea JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.sleepandbreathing-2017.P14 VL - 3 IS - suppl 1 SP - P14 AU - Marija Vukoja AU - Dragana Milicic AU - Aleksandar Bokan AU - Ilija Andrijevic AU - Ivan Kopitovic Y1 - 2017/04/01 UR - http://openres.ersjournals.com/content/3/suppl_1/P14.abstract N2 - Background Obstructive lung diseases have a significant impact on outcomes of patients with obstructive sleep apnea (OSA). Alternatively, functional changes in OSA may alter pulmonary mechanics, particularly the upper airway resistance.Aim To examine the pulmonary function test parameters in patients with OSA.Methods A cross-sectional study of patients who underwent overnight polysomnography at the Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia between November 2012 and May 2014. Spirometry, whole body plethysmography (BP) and impulse oscillometry (IOS) were performed in all patients.Results There were 118 patients, 85 (73%) men, mean age 49.5±18.1 years, mean BMI 30.3±12.1kg/m2. OSA was confirmed in 53 (44.9%) patients: 24 (20.2%) mild, 14 (11.8%) moderate and 15 (12.7%) severe. Obstructive ventilatory disorder consistent with chronic obstructive pulmonary disease (COPD) was confirmed by spirometry in 6/118 (5.1%) patients. There was no difference in the presence of COPD between patients with and without OSA (4/53, 7.55% vs. 2/63, 3.1%, p=0.46).When patients with COPD (n=6) and possible asthma (n=8) were excluded from the analysis airway resistance measured by BP (Rt median 0.2 IQR 1.015-0.26 vs. 0.16 IQR 0.12-0.21, p=0.01) and IOS (R5% median 120 IQR 92-187 vs. 104 IQR 85-122, p =0.01; R 20% median 123 IQR 97-164 vs. 108 IQR 81-129, p=0.03) were higher in patients with OSA compared to patients without OSA. When adjusted for age, gender, BMI and smoking, R5% was associated with the presence of OSA (OR 1.15 95%CI 1.03-1.32).Conclusions There is no difference in prevalence of COPD in patients with and without OSA. In patients without obstructive airway diseases, airway resistance measured by IOS is higher in OSA patients. ER -