RT Journal Article
SR Electronic
T1 A seven-year longitudinal study of bone mineral density in elderly with unrecognised obstructive sleep apnoea: the PROOF cohort study
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP P58
DO 10.1183/23120541.sleepandbreathing-2017.P58
VO 3
IS suppl 1
A1 Frederic Roche
A1 Philippe Collet
A1 Celine Philippon
A1 Jean Claude Barthelemy
A1 Hubert Marotte
A1 Emilia Sforza
A1 Thierry Thomas
YR 2017
UL http://openres.ersjournals.com/content/3/suppl_1/P58.abstract
AB Background Osteoporosis (OP) and obstructive sleep apnea (OSA) are two common serious disorders in the elderly associated. Although clinical studies suggest an association between these two diseases, their co-existence in elderly is controversial.Objectives This study explores the longitudinal changes on bone mineral density (BMD) in a large sample of older subjects with and without OSA.Methods 406 subjects, initially aged 68.8±1 y, were examined at baseline and after 7 y. At baseline they had anthropometric data, home polygraphy, assessment of daily energy expenditure, and dual-energy X-ray absorptiometry (DXA). At follow-up, clinical and DXA data were also collected.Results A significant decrease in prevalence of OP and osteopenia was present both at lumbar and femoral sites. Considering the changes in BMD and T-score according to severity of OSA, there was a significant decrease in cases with OP. After adjustment for gender, anthropometric and metabolic variables, univariate and multivariate regression analyses showed a significant association between changes of BMD and gender without contribution of metabolic and sleep related respiratory factors.Conclusions In older healthy subjects, a reduced prevalence of OP was found in a 7-y follow-up independently of the presence or not of OSA. The impact of chronic intermittent hypoxia on bone mineral loss appears quite limited in such an elderly population.