TY - JOUR T1 - FluoroType MTB system for the detection of pulmonary tuberculosis JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00113-2016 VL - 3 IS - 2 SP - 00113-2016 AU - Joshua Obasanya AU - Lovett Lawson AU - Thomas Edwards AU - Oladimeji Olanrewaju AU - Laura Madukaji AU - Russell Dacombe AU - Jose Dominguez AU - Barbara Molina-Moya AU - Emily R. Adams AU - Luis E. Cuevas Y1 - 2017/04/01 UR - http://openres.ersjournals.com/content/3/2/00113-2016.abstract N2 - Diagnosis continues to be a major barrier for the control of tuberculosis (TB), especially in low- and middle-income countries (LMIC) [1]. The number of platforms for the molecular diagnosis of TB have increased in recent years and they can provide test results more rapidly than culture. Molecular assays are increasingly being used as alternative or adjunct methods to culture and smear microscopy, and modern systems seek to partially or fully automate the DNA extraction and amplification steps, increasing their suitability for resource-limited laboratories. One of these platforms, the GeneXpert MTB/RIF (Cepheid, USA), has a sensitivity of roughly 85% compared to culture [2] and has seen significant uptake in developing countries [3]. However, as a fully closed system, the DNA extracted during the process cannot be used for further downstream drug susceptibility testing (DST), which is crucial for patients with suspected drug-resistant TB.FluoroType MTB is a sensitive test for TB but specificity is low compared with fully integrated molecular systems http://ow.ly/WhEO30b1luY ER -