RT Journal Article
SR Electronic
T1 Variations in the prevalence of childhood asthma and wheeze in MeDALL cohorts in Europe
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00150-2016
DO 10.1183/23120541.00150-2016
VO 3
IS 3
A1 Eleonora P. Uphoff
A1 Philippa K. Bird
A1 Joseph Maria Antó
A1 Mikel Basterrechea
A1 Andrea von Berg
A1 Anna Bergström
A1 Jean Bousquet
A1 Leda Chatzi
A1 Maria Pia Fantini
A1 Amparo Ferrero
A1 Ulrike Gehring
A1 Davide Gori
A1 Joachim Heinrich
A1 Thomas Keil
A1 Inger Kull
A1 Susanne Lau
A1 Dieter Maier
A1 Isabelle Momas
A1 Silvia Narduzzi
A1 Daniela Porta
A1 Fanny Ranciere
A1 Theano Roumeliotaki
A1 Tamara Schikowski
A1 Henriette A. Smit
A1 Marie Standl
A1 Jordi Sunyer
A1 John Wright
YR 2017
UL http://openres.ersjournals.com/content/3/3/00150-2016.abstract
AB While there is evidence for variations in prevalence rates of childhood wheeze and asthma between countries, longitudinal, individual-level data are needed to understand these differences. The aim of this study was to examine variations in prevalence rates of childhood asthma, wheeze and wheeze with asthma in Europe.We analysed datasets from 10 MeDALL (Mechanisms of the Development of ALLergy) cohorts in eight countries, representing 26 663 children, to calculate prevalence rates of wheeze and asthma by child age and wheeze with asthma at age 4 years. Harmonised variables included outcomes parent-reported wheeze and parent-reported doctor-diagnosed asthma, and covariates maternal education, parental smoking, pets, parental asthma, doctor-diagnosed allergic rhinitis, doctor-diagnosed eczema and wheeze severity.At age 4 years, asthma prevalence varied from 1.72% in Germany to 13.48% in England and the prevalence of wheeze varied from 9.82% in Greece to 55.37% in Spain. Adjusted estimates of the proportion of 4-year-old children with wheeze diagnosed with asthma remained highest in England (38.14%, 95% CI 31.38–44.90%) and lowest in Spain (15.94%, 95% CI 6.16–25.71%).The large differences in prevalence rates of asthma, wheeze and wheeze with asthma at age 4 years between European cohorts may indicate that childhood asthma is more readily diagnosed in some countries while going unrecognised elsewhere.Large variations in childhood wheeze across Europe do not match large variations in diagnosed childhood asthma http://ow.ly/eJQk30aPInr