RT Journal Article
SR Electronic
T1 EBUS-TBNA in PET-positive lymphadenopathies in treated cancer patients
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00009-2017
DO 10.1183/23120541.00009-2017
VO 3
IS 4
A1 Juliana Guarize
A1 Monica Casiraghi
A1 Stefano Donghi
A1 Chiara Casadio
A1 Cristina Diotti
A1 Niccolò Filippi
A1 Clementina Di Tonno
A1 Valeria Midolo
A1 Patrick Maisonneuve
A1 Daniela Brambilla
A1 Chiara Maria Grana
A1 Francesco Petrella
A1 Lorenzo Spaggiari
YR 2017
UL http://openres.ersjournals.com/content/3/4/00009-2017.abstract
AB Mediastinal lymph node enlargement is common in the follow-up of patients with previously treated malignancies. The aim of this study is to assess the role of endobronchial ultrasound (EBUS) transbronchial needle aspiration (TBNA) for cyto-histological evaluation of positron emission tomography with 18fluorodeoxyglucose (PET) positive mediastinal and hilar lymph nodes developed in patients with previous malignancies.All EBUS-TBNA cases performed from January 2012 to May 2016 were retrospective reviewed. Results of EBUS-TBNA in patients with mediastinal and/or hilar lymphadenopathies were analysed. Non-malignant cytopathologies were confirmed with surgical procedures or clinical and radiological follow-up.Among 1780 patients, 176 were included in the analysis. 103 of these (58.5%) had a diagnosis of tumour recurrence whereas 73 (41.5%) had a different diagnosis: 63 (35.8%) had a non-neoplastic diagnosis and 8 patients (4.6%) had a different cell type malignancy. Samples were false-negative in 5 (2.8%) out of 176 patients. The overall sensitivity, specificity, negative predicted value and diagnostic accuracy were 95.7% (95% CI 90.2–98.6%), 100% (95% CI 94.0–100%), 92.3% (95% CI 83.2–96.7%) and 97.2% (95% CI 93.5–98.8%), respectively.EBUS-TBNA demonstrated a pathological diagnosis different from the previous tumour in a large percentage of patients, confirming its strategic role in the management of patients with previously treated malignancies.EBUS-TBNA changes the management of treated cancer patients http://ow.ly/vTnh30fBFaE