TY - JOUR T1 - Decrease in pulmonary function and oxygenation after lung resection JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00055-2017 VL - 4 IS - 1 SP - 00055-2017 AU - Barbara Cristina Brocki AU - Elisabeth Westerdahl AU - Daniel Langer AU - Domingos S.R. Souza AU - Jan Jesper Andreasen Y1 - 2018/01/01 UR - http://openres.ersjournals.com/content/4/1/00055-2017.abstract N2 - Respiratory deficits are common following curative intent lung cancer surgery and may reduce the patient's ability to be physically active. We evaluated the influence of surgery on pulmonary function, respiratory muscle strength and physical performance after lung resection.Pulmonary function, respiratory muscle strength (maximal inspiratory/expiratory pressure) and 6-min walk test (6MWT) were assessed pre-operatively, 2 weeks post-operatively and 6 months post-operatively in 80 patients (age 68±9 years).Video-assisted thoracoscopic surgery was performed in 58% of cases. Two weeks post-operatively, we found a significant decline in pulmonary function (forced vital capacity −0.6±0.6 L and forced expiratory volume in 1 s −0.43±0.4 L; both p<0.0001), 6MWT (−37.6±74.8 m; p<0.0001) and oxygenation (−2.9±4.7 units; p<0.001), while maximal inspiratory and maximal expiratory pressure were unaffected. At 6 months post-operatively, pulmonary function and oxygenation remained significantly decreased (p<0.001), whereas 6MWT was recovered.We conclude that lung resection has a significant short- and long-term impact on pulmonary function and oxygenation, but not on respiratory muscle strength. Future research should focus on mechanisms negatively influencing post-operative pulmonary function other than impaired respiratory muscle strength.Lung resection has a significant short- and long-term impact on pulmonary function and oxygenation, but not on respiratory muscle strength http://ow.ly/WTqc30h6j4i ER -