RT Journal Article SR Electronic T1 Early diagnosis from newborn screening maximises survival in severe cystic fibrosis JF ERJ Open Research JO erjor FD European Respiratory Society SP 00109-2017 DO 10.1183/23120541.00109-2017 VO 4 IS 2 A1 Gloria Tridello A1 Carlo Castellani A1 Ilaria Meneghelli A1 Anna Tamanini A1 Baroukh M. Assael YR 2018 UL http://openres.ersjournals.com/content/4/2/00109-2017.abstract AB Newborn screening (NBS) for cystic fibrosis (CF) has been gradually established in several countries, but scant data are available on its long-term effects on survival. Our objective was to evaluate the long-term effects of CF NBS on survival.586 patients, diagnosed and followed between 1971 and 2014 at the Verona CF Centre were analysed. Eligibility was confirmed in 342 cases diagnosed by NBS, 101 with meconium ileus and 143 through symptoms (44 out of 143 were NBS false negatives). The primary end-point was the 30-year overall survival in patients diagnosed by NBS. Patients were grouped according to the number of hospitalisations for respiratory or nutritional symptoms in the first 3 years of life: 0 (mild), 1–2 (moderate) and ≥3 (severe). Survival in NBS and symptoms groups was compared.The 30-year survival probability of the NBS group was 80.1% (95% CI 71.4–86.4%); in the symptoms group it was 71.0% (95% CI 62.2–78.2%). The 20-year survival was significantly higher in the NBS versus symptoms group in the severe (85% versus 64%, p=0.007) and moderate (94% versus 86%, p=0.016) groups. An adjusted Cox-model estimation confirmed differences in both the groups.Poor outcome associated with early severe presentation of CF is tempered by NBS.Cystic fibrosis newborn screening maximises survival in patients with early severe presentation of the disease http://ow.ly/lCOJ30iGHI6