TY - JOUR T1 - Understanding asthma phenotypes: the World Asthma Phenotypes (WASP) international collaboration JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00013-2018 VL - 4 IS - 3 SP - 00013-2018 AU - Lucy Pembrey AU - Mauricio L. Barreto AU - Jeroen Douwes AU - Philip Cooper AU - John Henderson AU - Harriet Mpairwe AU - Cristina Ardura-Garcia AU - Martha Chico AU - Collin Brooks AU - Alvaro A. Cruz AU - Alison M. Elliott AU - Camila A. Figueiredo AU - Sinéad M. Langan AU - Beatrice Nassanga AU - Susan Ring AU - Laura Rodrigues AU - Neil Pearce Y1 - 2018/07/01 UR - http://openres.ersjournals.com/content/4/3/00013-2018.abstract N2 - The World Asthma Phenotypes (WASP) study started in 2016 and has been conducted in five centres, in the UK, New Zealand, Brazil, Ecuador and Uganda.The objectives of this study are to combine detailed biomarker and clinical information in order to 1) better understand and characterise asthma phenotypes in high-income countries (HICs) and low and middle-income countries (LMICs), and in high and low prevalence centres; 2) compare phenotype characteristics, including clinical severity; 3) assess the risk factors for each phenotype; and 4) assess how the distribution of phenotypes differs between high prevalence and low prevalence centres.Here we present the rationale and protocol for the WASP study to enable other centres around the world to carry out similar analyses using a standardised protocol. Large collaborative and integrative studies like this are essential to further our understanding of asthma phenotypes. The findings of this study will help elucidate the aetiological mechanisms of asthma and might potentially identify new causes and guide the development of new treatments, thereby enabling better management and prevention of asthma in both HICs and LMICs.A protocol for the World Asthma Phenotypes study to better understand and characterise asthma phenotypes in five centres in the UK, New Zealand, Brazil, Ecuador and Uganda http://ow.ly/71CR30ldsU4 ER -