RT Journal Article
SR Electronic
T1 Understanding asthma phenotypes: the World Asthma Phenotypes (WASP) international collaboration
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00013-2018
DO 10.1183/23120541.00013-2018
VO 4
IS 3
A1 Lucy Pembrey
A1 Mauricio L. Barreto
A1 Jeroen Douwes
A1 Philip Cooper
A1 John Henderson
A1 Harriet Mpairwe
A1 Cristina Ardura-Garcia
A1 Martha Chico
A1 Collin Brooks
A1 Alvaro A. Cruz
A1 Alison M. Elliott
A1 Camila A. Figueiredo
A1 Sinéad M. Langan
A1 Beatrice Nassanga
A1 Susan Ring
A1 Laura Rodrigues
A1 Neil Pearce
YR 2018
UL http://openres.ersjournals.com/content/4/3/00013-2018.abstract
AB The World Asthma Phenotypes (WASP) study started in 2016 and has been conducted in five centres, in the UK, New Zealand, Brazil, Ecuador and Uganda.The objectives of this study are to combine detailed biomarker and clinical information in order to 1) better understand and characterise asthma phenotypes in high-income countries (HICs) and low and middle-income countries (LMICs), and in high and low prevalence centres; 2) compare phenotype characteristics, including clinical severity; 3) assess the risk factors for each phenotype; and 4) assess how the distribution of phenotypes differs between high prevalence and low prevalence centres.Here we present the rationale and protocol for the WASP study to enable other centres around the world to carry out similar analyses using a standardised protocol. Large collaborative and integrative studies like this are essential to further our understanding of asthma phenotypes. The findings of this study will help elucidate the aetiological mechanisms of asthma and might potentially identify new causes and guide the development of new treatments, thereby enabling better management and prevention of asthma in both HICs and LMICs.A protocol for the World Asthma Phenotypes study to better understand and characterise asthma phenotypes in five centres in the UK, New Zealand, Brazil, Ecuador and Uganda http://ow.ly/71CR30ldsU4