TY - JOUR T1 - Effect of intermittent inspiratory leaks on measurement of lung clearance index using nitrogen and sulfur hexafluoride JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00140-2018 VL - 4 IS - 4 SP - 00140-2018 AU - Florian Singer AU - Kathryn Ramsey AU - Philipp Latzin Y1 - 2018/10/01 UR - http://openres.ersjournals.com/content/4/4/00140-2018.abstract N2 - We thank C.A. Whitfield and colleagues for their interest in our study [1], and agree that the effects of leaks on multiple-breath washout (MBW) outcomes are dependent on the type of tracer gas. Efforts should be made to develop an online feedback to inform operators of the tightness or leakiness of the system [2].Nitrogen MBW is susceptible to leaks; effects of leaks on sulfur hexafluoride MBW require further study http://ow.ly/iY6o30lGchV ER -