RT Journal Article
SR Electronic
T1 Pulmonary vascular pruning in smokers with bronchiectasis
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00044-2018
DO 10.1183/23120541.00044-2018
VO 4
IS 4
A1 Alejandro A. Diaz
A1 Diego J. Maselli
A1 Farbod Rahaghi
A1 Carolyn E. Come
A1 Andrew Yen
A1 Erick S. Maclean
A1 Yuka Okajima
A1 Carlos H. Martinez
A1 Tsuneo Yamashiro
A1 David A. Lynch
A1 Wei Wang
A1 Gregory L. Kinney
A1 George R. Washko
A1 Raúl San José Estépar
YR 2018
UL http://openres.ersjournals.com/content/4/4/00044-2018.abstract
AB There are few studies looking at the pulmonary circulation in subjects with bronchiectasis. We aimed to evaluate the intraparenchymal pulmonary vascular structure, using noncontrast chest computed tomography (CT), and its clinical implications in smokers with radiographic bronchiectasis.Visual bronchiectasis scoring and quantitative assessment of the intraparenchymal pulmonary vasculature were performed on CT scans from 486 smokers. Clinical, lung function and 6-min walk test (6MWT) data were also collected. The ratio of blood vessel volume in vessels <5 mm2 in cross-section (BV5) to total blood vessel volume (TBV) was used as measure of vascular pruning, with lower values indicating more pruning. Whole-lung and lobar BV5/TBV values were determined, and regression analyses were used to assess the differences in BV5/TBV between subjects with and without bronchiectasis.155 (31.9%) smokers had bronchiectasis, which was, on average, mild in severity. Compared to subjects without bronchiectasis, those with lower-lobe bronchiectasis had greater vascular pruning in adjusted models. Among subjects with bronchiectasis, those with vascular pruning had lower forced expiratory volume in 1 s and 6MWT distance compared to those without vascular pruning.Smokers with mild radiographic bronchiectasis appear to have pruning of the distal pulmonary vasculature and this pruning is associated with measures of disease severity.Smokers with radiographic bronchiectasis have intraparenchymal pulmonary vascular pruning, which is associated with both lung function and exercise capacity impairment http://ow.ly/YCYm30mgV7z