TY - JOUR T1 - Randomised controlled trial of cognitive behavioural therapy in COPD JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00094-2018 VL - 4 IS - 4 SP - 00094-2018 AU - Karen Heslop-Marshall AU - Christine Baker AU - Debbie Carrick-Sen AU - Julia Newton AU - Carlos Echevarria AU - Chris Stenton AU - Michelle Jambon AU - Joanne Gray AU - Kim Pearce AU - Graham Burns AU - Anthony De Soyza Y1 - 2018/10/01 UR - http://openres.ersjournals.com/content/4/4/00094-2018.abstract N2 - Anxiety is an important comorbidity in chronic obstructive pulmonary disease (COPD). We investigated if cognitive behavioural therapy (CBT), delivered by respiratory nurses, reduced symptoms of anxiety and was cost-effective.Patients with COPD and anxiety were randomised to CBT or self-help leaflets. Anxiety, depression and quality of life were measured at baseline, 3, 6 and 12 months. A cost-effectiveness analysis was conducted from a National Health Service hospital perspective and quality-adjusted life-years estimated using the EuroQol-5D questionnaire.In total, 279 patients were recruited. Group mean change from baseline to 3 months in the Hospital Anxiety and Depression Anxiety Subscale was 3.4 (95% CI 2.62–4.17, p<0.001) for the CBT group and 1.88 (95% CI 1.19–2.55, p<0.001) in the leaflet group. The CBT group was superior to leaflets at 3 months (mean difference in the Hospital Anxiety and Depression Anxiety Subscale was 1.52, 95% CI 0.49–2.54, p=0.003). Importantly, the CBT intervention was more cost-effective than leaflets at 12 months, significantly lowering hospital admissions and attendance at emergency departments.CBT delivered by respiratory nurses is a clinically and cost-effective treatment for anxiety in patients with COPD relative to self-help leaflets.Cognitive behavioural therapy (CBT) delivered by respiratory nurses is clinically effective and cost-effective for patients with chronic obstructive pulmonary disease and symptoms of anxiety http://ow.ly/o41o30msBNy ER -