TY - JOUR T1 - Persistent symptoms 3 months after a SARS-CoV-2 infection: the post-COVID-19 syndrome? JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00542-2020 VL - 6 IS - 4 SP - 00542-2020 AU - Yvonne M.J. Goërtz AU - Maarten Van Herck AU - Jeannet M. Delbressine AU - Anouk W. Vaes AU - Roy Meys AU - Felipe V.C. Machado AU - Sarah Houben-Wilke AU - Chris Burtin AU - Rein Posthuma AU - Frits M.E. Franssen AU - Nicole van Loon AU - Bita Hajian AU - Yvonne Spies AU - Herman Vijlbrief AU - Alex J. van ’t Hul AU - Daisy J.A. Janssen AU - Martijn A. Spruit Y1 - 2020/10/01 UR - http://openres.ersjournals.com/content/6/4/00542-2020.abstract N2 - Background Many patients with COVID-19 did not require hospitalisation, nor underwent COVID-19 testing. There is anecdotal evidence that patients with “mild” COVID-19 may complain about persistent symptoms, even weeks after the infection. This suggests that symptoms during the infection may not resolve spontaneously. The objective of this study was to assess whether multiple relevant symptoms recover following the onset of symptoms in hospitalised and nonhospitalised patients with COVID-19.Methods A total of 2113 members of two Facebook groups for coronavirus patients with persistent complaints in the Netherlands and Belgium, and from a panel of people who registered on a website of the Lung Foundation Netherlands, were assessed for demographics, pre-existing comorbidities, health status, date of symptoms onset, COVID-19 diagnosis, healthcare utilisation, and the presence of 29 symptoms at the time of the onset of symptoms (retrospectively) and at follow-up (mean±sd 79±17 days after symptoms onset).Results Overall, 112 hospitalised patients and 2001 nonhospitalised patients (confirmed COVID-19, n=345; symptom-based COVID-19, n=882; and suspected COVID-19, n=774) were analysed. The median number of symptoms during the infection reduced significantly over time (median (interquartile range) 14 (11–17) versus 6 (4–9); p<0.001). Fatigue and dyspnoea were the most prevalent symptoms during the infection and at follow-up (fatigue: 95% versus 87%; dyspnoea: 90% versus 71%).Conclusion In previously hospitalised and nonhospitalised patients with confirmed or suspected COVID-19, multiple symptoms are present about 3 months after symptoms onset. This suggests the presence of a “post-COVID-19 syndrome” and highlights the unmet healthcare needs in a subgroup of patients with “mild” or “severe” COVID-19.Previously hospitalised and nonhospitalised #COVID19 patients can still have multiple persistent symptoms 3 months after the onset of infection-related symptoms. This provides the first evidence for a “post-COVID-19 syndrome” #longCOVID https://bit.ly/3h8iJ80 ER -