Worst grade 3–4 toxicity observed during VAC plus valproic acid administration in relapsed/refractory small cell lung cancer patients
| Nonhaematological toxicity | |
| Nausea and vomiting | 1 (2) |
| Infection | 2 (4) |
| Bleeding | 1 (2) |
| Neurological encephalopathy | 2 (4) |
| Respiratory | 3 (7) |
| Cardiac | 1 (2) |
| Febrile neutropenia | 13 (26) |
| Haematological toxicity | |
| Leukopenia | 43 (86) |
| Thrombopenia | 13 (26) |
| Neutropenia | 44 (88) |
Data are presented as n (%). VAC: doxorubicin, vindesine and cyclophosphamide.