Non-synonymous sequence variants of antibiotic resistance genes in Staphylococcus aureus and Pseudomonas aeruginosa populations of cystic fibrosis sputum metagenomes#
| Organism | Gene | Amino acid substitution | Patients n (samples n) |
| S. aureus | gyrA | p.Ser90Leu | 2 (4 and 2 from each patient) |
| p.Leu576Phe | 1 (1) | ||
| p.Arg843His | 1 (1) | ||
| p.Thr833fs | 1 (1) | ||
| p.Asp891_Glu892dup | 1 (2) | ||
| rpoB | p.Asp320Asn | 1 (1) | |
| parE | p.Asn139Ser | 2 (2 and 1 from each patient) | |
| p.Gly530Asp | 1 (1) | ||
| P. aeruginosa | mexS | p.Ala235Thr | 1 (3) |
| p.Arg48His | 1 (1) | ||
| mexI | p.Ala782Glu | 2 (1 from each patient) |
#: 353 single-nucleotide polymorphisms were identified in total. The table displays a selection of rare non-conservative coding variants in targets of antimicrobial chemotherapy and antibiotic resistance determinants.