TABLE 4

Correlation between in vivo inflammation and physiological bronchodilator response

	FEV₁ % change		Δ R₂₀		Δ R_5–20		Δ X₅
	ρ	p-value	ρ	p-value	ρ	p-value	ρ	p-value
Inflammatory cells
Neutrophils	0.02	ns	0.09	ns	−0.30	ns	0.40	ns
Chemokines
IL-8	0.12	ns	0.04	ns	−0.51	0.021	0.71	<0.001^#
Eotaxin	0.26	ns	−0.13	ns	−0.52	0.016	0.66	0.001^#
Fractalkine	0.28	ns	−0.02	ns	−0.58	0.006	0.65	0.001^#
IL-12 p70	0.28	ns	−0.03	ns	−0.47	0.032	0.56	0.008^#
TGF-α	0.26	ns	−0.06	ns	−0.39	ns	0.56	0.008^#

FEV₁: forced expiratory volume in 1 s; R_x: resistance at x Hz; X₅: dynamic elastance at 5 Hz; IL: interleukin; TGF: transforming growth factor; ns: nonsignificant. ^#: statistically significant after correction for multiple comparisons.