Characteristics of ongoing studies
| Study name or title | Chief investigator | Study period (start and end dates) (country) | Study design | Participants | Intervention | Comparison | Outcomes |
| Pulmonary Rehabilitation and ACTIvity after COPD Exacerbations: the PRACTICE trial: a randomised trial [24] | R. Hughes | January 2015 to December 2016 (UK) | Parallel group, randomised pilot 2×2 trial | 76 participants with clinically identified exacerbation of diagnosed COPD | 1) In-hospital exercise training followed by in-home post-discharge early rehabilitation; 2) standard in-hospital care followed by in-home post-discharge early rehabilitation | 1) In-hospital exercise training followed by standard discharge care; 2) standard in-hospital care followed by standard discharge | Subsequent uptake, adherence and completion of group-based community pulmonary rehabilitation |
| Video to Increase RehabiliTation Uptake following hospitalised Exacerbations of COPD (VIRTUE): a randomised controlled trial [25] | W. Man | January 2015 to January 2017 (UK) | Parallel group, randomised trial | 200 adults aged >40 years diagnosed with COPD, admitted to hospital with acute exacerbation of COPD and fit enough to take part in pulmonary rehabilitation | Participants will be asked to watch a 5-min patient-designed video promoting early pulmonary rehabilitation plus usual care | Usual care: provided with standard verbal information and an A5 patient information leaflet about early pulmonary rehabilitation | Uptake, adherence and completion of post-exacerbation pulmonary rehabilitation |
| A tailored, psychological intervention for mild to moderate anxiety or depression in people with COPD: Tailored intervention for ANxiety and DEpression Management in COPD (TANDEM) [26] | S. Taylor | April 2016 to January 2021 (UK) | Three-phase study (phase I: preparation; phase II: pilot randomised controlled trial; phase III: a fully powered individually randomised controlled trial) | Adults with moderate–severe COPD with mild–moderate comorbid anxiety or depression and eligible for attendance at their local pulmonary rehabilitation; phase II: 45 participants; phase III: 430 participants | Tailored, one-to-one psychological intervention combined with practical problem-solving components based on: Self-management Programme of Activity Coping and Education (SPACE) and The Lung Manual, a nurse-led intervention based on cognitive behavioural principles and self-management, and developed to address mood disorders of anxiety in COPD; this psychological intervention links into, and interdigitates with, usual pulmonary rehabilitation, but is independent of it | Usual care: standard pulmonary rehabilitation without interdigitating psychological intervention | Uptake and completion of pulmonary rehabilitation (to be informed by the pre-pilot and pilot studies) |
COPD: chronic obstructive pulmonary disease.