Absolute difference in relevant respiratory outcomes between tuberculosis (TB) patients compared with community controls
| Outcome | DS-TB | MDR-TB | ||
| Absolute difference (95% CI) | p-value | Absolute difference (95% CI) | p-value | |
| FeNO ppb# | ||||
| Univariate | 1.12 (0.98–1.28) | 0.11 | 0.93 (0.74–1.16) | 0.53 |
| Multivariate | 1.15 (1.01–1.32) | 0.04 | 0.99 (0.79–1.25) | 0.94 |
| 6MWD m | ||||
| Univariate | 4.13 (−10.80–19.06) | 0.59 | 3.01 (−21.79–27.80) | 0.81 |
| Multivariate | 1.03 (−14.14–16.20) | 0.89 | −2.40 (−27.46–22.65) | 0.85 |
| FEV1 L | ||||
| Univariate | −0.02 (−0.17–0.13) | 0.82 | −0.482 (−0.727– −0.237) | <0.01 |
| Multivariate | −0.07 (−0.23–0.08) | 0.34 | −0.431 (−0.679– −0.183) | <0.01 |
| FVC L | ||||
| Univariate | 0.04 (−0.12–0.21) | 0.61 | −0.426 (−0.697– −0.156) | <0.01 |
| Multivariate | −0.01 (−0.18–0.15) | 0.88 | −0.370 (−0.644– −0.097) | <0.01 |
| FEV1/FVC | ||||
| Univariate | −0.02 (−0.04–0.01) | 0.13 | −0.059 (−0.099– −0.019) | <0.01 |
| Multivariate | −0.02 (−0.05–0.00) | 0.10 | −0.054 (−0.096– −0.012) | 0.01 |
DS: drug-susceptible; MDR: multidrug-resistant; FeNO: fraction of exhaled nitric oxide; 6MWD: 6-min walk distance; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity. FEV1, FVC and FEV1/FVC all refer to best post-bronchodilator values that fulfilled quality control requirements. Univariate analysis unadjusted except for FEV1, FVC and FEV1/FVC, which were adjusted for age and sex, and FEV1 and FVC, which were adjusted for height. Multivariate analysis adjusted for the following covariates: current or former smoking, exposure to environmental tobacco smoke (any), indoor air pollution using bio-combustible fuel (ever), occupational dust exposure (>6 months), born outside of Lima and presence of atopy. #: effect on FeNO expressed as ratio (exponent of the regression coefficient of group variable, with logFeNO as the dependent variable).