Characteristics of CHP cohort# | No IS¶ | IS+ | p-value |
Age years | 65.1±10 | 61.1±12 | 0.07 |
Male | 19 (50%) | 34 (37%) | 0.16 |
Caucasian race/ethnicity | 31 (82%) | 80 (86%) | 0.52 |
BMI kg·m−2 | 33.0±9 | 32.6±9 | 0.83 |
Ever-smoker | 20 (53%) | 54 (58%) | 0.57 |
Antigen exposure§ | |||
Avian | 19 (50%) | 42 (45%) | 0.61 |
Mould | 11 (29%) | 28 (30%) | 0.90 |
Hot tub | 1 (3%) | 2 (2%) | 0.99 |
Unknown | 11 (29%) | 29 (31%) | 0.80 |
Gastro-oesophageal reflux | 20 (53%) | 58 (62%) | 0.30 |
Crackles | 28 (73%) | 85 (91%) | 0.008 |
Clubbing | 3 (8%) | 26 (28%) | 0.012 |
TLCƒ % predicted | 79.7±19 | 69.0±17 | 0.002 |
FVC## % predicted | 73.3±19 | 60.0±17 | <0.001 |
DLCO¶¶ % predicted | 69.2±23 | 47.2±22 | <0.001 |
Oxygen therapy | 9 (24%) | 66 (71%) | <0.001 |
ANA seropositivity | 11 (31%) | 26 (29%) | 0.78 |
HRCT features | |||
HRCT fibrosis score | 117.8±10 | 125.9±18 | 0.01 |
Mosaic attenuation | 31 (82%) | 81 (87%) | 0.42 |
Ground-glass opacities | 33 (87%) | 86 (93%) | 0.31 |
Honeycombing | 14 (37%) | 42 (45%) | 0.38 |
Histopathological features | |||
SLB obtained | 18 (47%) | 62 (67%) | 0.04 |
Poorly formed granulomas | 11 (61%) | 41 (66%) | 0.69 |
Honeycombing with UIP pattern | 7 (39%) | 29 (47%) | 0.55 |
Follow-up time months | 43±30 | 38±27 | 0.37 |
Data are presented as mean±sd or n (%). CHP: chronic hypersensitivity pneumonitis; IS: immunosuppressive therapy; BMI: body mass index; TLC: total lung capacity; FVC: forced vital capacity; DLCO: diffusing capacity of the lung for carbon monoxide; ANA: antinuclear antibody; HRCT: high-resolution computed tomography; SLB: surgical lung biopsy; UIP: usual interstitial pneumonia. #: n=131. ¶: n=38. +: n=93. §: a historical assessment of environmental antigen exposures (avian, mould, hot tub and unknown) is performed for all patients in the University of Chicago interstitial lung disease registry, regardless of referring diagnosis; the presence of antibodies to serum precipitins supported the diagnosis but was not a requirement; ANA was evaluated in 125 patients, threshold used for seropositive titre ≥1:320. ƒ: exception for patients, n=127. ##: exception for patients, n=130. ¶¶: exception for patients, n=116.