Baseline | 2 weeks | Change | 6 months | Change | |||
Baseline to 2 weeks | p-value | Baseline to 6 months | p-value | ||||
Patients | 80 | 80 | 65 | ||||
FVC L | 3.4±0.9 3.4 (1.5–5.6) | 2.8±0.9 2.8 (1–5) | −0.6±0.6 −0.6 (−2.5–0.7) | <0.0001 | 3.2±0.1 3.1 (1.3–5.7) | −0.29±0.5 −0.29 (−1.7–0.8) | <0.0001 |
FVC % pred | 101±21 98 (59–170) | 83±21 83 (35–131) | −17.6±17.6 −16 (−7.6–17) | <0.0001 | 94±21.9 91 (56–150) | −8.9±17.7 −7 (−6.6–30) | <0.0001 |
FEV1 L | 2.3±0.8 2.2 (0.7–4.2) | 1.8±0.7 1.8 (0.6–3.6) | −0.43±0. 4 −0.43 (−1.6–0.3) | <0.0001 | 2.1±0.7 2.1 (0.8–4) | −0.27±0.3 −0.2 (−0.9–0.5) | <0.001 |
FEV1 % pred | 83±21.4 86 (28–134) | 68±20.3 66 (20–118) | −15.2±14.1 −16 (−55–16) | <0.0001 | 76±18.5 75 (28–120) | −9.6±11.4 −9 (−42–19) | <0.0001 |
FEV1/FVC | 66±12.9 68.4 (21.6–85) | 65±12.5 65.5 (39–88.6) | −0.92±7.69 12 (−18.6–20.5) | 0.17 | 65±11.5 65.1 (32.5–87.6) | −2.12±7.12 −2.5 (−16.7–17.9) | 0.002 |
FEV1/FVC % pred | 87±17.3 91 (29–111) | 86±16 87 (52–119) | −0.9±1 −0.1 (−25–29) | 0.28 | 86±15 87 (43–114) | −2±1 −3 (−21–24) | 0.017 |
Data are presented as n, mean±sd or median (minimum–maximum range), unless otherwise stated. FVC: forced vital capacity; FEV1: forced expiratory volume in 1 s. Statistical analysis by Wilcoxon signed-rank test.