TABLE 2

Empirical antibiotic treatments for high-risk patients

High risk of multidrug resistance and/or >15% risk of mortality in ICU	No septic shock	Monotherapy against Gram-negative (if active against >90% of the probable ICU pathogens) ± MRSA treatment
	Septic shock	Dual treatment with Pseudomonas Gram-negative coverage ± MRSA treatment

ICU: intensive care unit; MRSA: methicillin-resistant Staphylococcus aureus.