Variables | Change from baseline mean±sd | Treatment effect mean change (95% CI) | p-value# | |
Bosentan | Bosentan/metformin | |||
6MWD m | 48±119 | 95±136 | 52 (10–95) | 0.017 |
NT-proBNP ng·L−1 | −176±325 | −183±415 | −141 (−236– −47) | 0.094 |
Mean PAP mmHg | −12±15 | −20±19 | −3 (−7–1) | 0.145 |
PVR index WU·m−2 | −1.2±1.3 | −1.8±1.2 | −0.8 (−1.2– −0.4) | <0.001 |
PVR/SVR ratio | −0.07±0.19 | −0.11±0.19 | −0.10 (−0.63–0.43) | 0.148 |
Cardiac index L·min−1·m−2 | 0.3±0.5 | 0.3±0.4 | 0.11 (−0.61–0.28) | 0.27 |
6MWD: 6-min walking distance; NT-proBNP: N-terminal pro-brain natriuretic peptide; PAP: pulmonary arterial pressure; PVR: pulmonary vascular resistance; WU: Wood unit; SVR: systemic vascular resistance.#: ANCOVA adjusted for a baseline covariate.