Characteristic | PrePH | IpcPH | CpcPH | PH (not pre or post) | No PH |
Subjects n | 15 | 5 | 3 | 2 | 7 |
Age | 55 (51–62) | 62 (65–73) | 66 (62–70) | 58 (58–58) | 54 (40–70) |
Female sex n | 7 | 2 | 3 | 1 | 6 |
Race n | |||||
White | 9 | 4 | 3 | 2 | 7 |
Black | 5 | 0 | 0 | 0 | 0 |
Smoker n | 4 | 2 | 1 | 2 | 1 |
WHO functional class n | |||||
Class 1 | 2 | 2 | 2 | 2 | 0 |
Class 2 | 8 | 3 | 0 | 0 | 5 |
Class 3 | 3 | 0 | 1 | 0 | 2 |
Class 4 | 1 | 0 | 0 | 0 | 0 |
Medications n | |||||
PDE5 inhibitor | 1 | 0 | 1 | 0 | 1 |
Endothelin receptor antagonist | 6 | 0 | 0 | 0 | 0 |
Pulmonary function tests | |||||
FEV1 % pred | 57 (42–71) | 63 (51–68) | 68 (66–71) | 82 (75–88) | 92 (54–110) |
FVC % pred | 66 (57–75) | 67 (50–72) | 78 (76–81) | 86 (73–99) | 86 (53–113) |
FEV1/FVC % | 84 (78–96) | 102 (101–104) | 85 (80–90) | 100 (92–107) | 79 (74–106) |
TLC % pred | 83 (72–91) | 79 (60–90) | 83 (80–88) | 114 (114–114) | 123 (114–132) |
DLCO % pred | 55 (32–75) | 75 (69–88) | 67 (61–73) | 83 (61–104) | 84 (40–128) |
Invasive haemodynamics (RHC) | |||||
Cardiac index L·min−1·m−2 | 2.9 (2.4–2.8) | 2.7 (2.5–2.8) | 2.2 (2.0–2.4) | 2.9 (2.4–3.5) | 3.1 (2.6–3.7) |
RA pressure mmHg | 9 (6–11) | 10 (8–12) | 12 (12–12) | 6 (6–6) | 4.5 (3.0–6.0) |
PCWP mmHg | 12 (10–14) | 18 (16–19) | 18 (17–19) | 12 (10–13) | 10 (9–12) |
PA mean pressure mmHg | 41 (34–48) | 29 (25–32) | 49 (46–52) | 26 (25–27) | 17 (15–19) |
PVR Wood units | 5.6 (4.3–6.9) | 1.8 (1.2–2.2) | 7.6 (6.5–8.3) | 2.6 (2.4–2.7) | 1.1 (0.6–1.5) |
Echocardiographic parameters | |||||
LV ejection fraction % | 61 (60–65) | 62 (60–65) | 63 (63–65) | 58 (56–59) | 53 (45–60) |
Tricuspid regurgitation n | |||||
0 – trivial | 2 | 2 | 2 | 2 | 0 |
1 – mild | 8 | 3 | 0 | 0 | 4 |
2 – moderate | 3 | 0 | 1 | 0 | 3 |
3 – severe | 1 | 0 | 0 | 0 | 0 |
TAPSE cm | 2.0 (1.6–2.7) | 2.7 (2.3–2.7) | 1.5 (1.4–1.7) | 2.5 (2.4–2.6) | 1.6 (1.4–1.8) |
RVSP mmHg | 52 (36–67) | 35 (29–41) | 56 (47–72) | 15 (15–15) | 20 (15–25) |
Resting heart rate | 71 (69–81) | 74 (68–83) | 79 (74–83) | 83 (81–84) | 83 (74–88) |
Data are either presented as number of participants or as median (IQR) where the first number in parentheses is the first quartile and the second number in parentheses is the third quartile. One prePH subject and one no PH subject did not have echocardiography results and are omitted from echocardiographic parameters. PH: pulmonary hypertension; PrePH: pre-capillary PH; IcpPH: isolated post-capillary PH; CpcPH: combined post- and pre-capillary PH; WHO: World Health Organisation; FEV1 % pred: percentage of predicted forced expiratory volume in 1 s; FVC % pred: percentage of predicted forced vital capacity; TLC % pred: percentage of predicted total lung capacity; DLCO % pred: percentage of predicated diffusing capacity of the lung for carbon monoxide; RHC: right heart catheterisation; RA: right atrial; PCWP: pulmonary capillary wedge pressure; PA: pulmonary artery; PVR: pulmonary vascular resistance; LV: left ventricular; TAPSE: tricuspid annular plane systolic excursion; RVSP: right ventricular systolic pressure.