Clinical lung and heart/lung transplantationEffect of Preoperative Pulmonary Artery Pressure on Early Survival After Lung Transplantation for Idiopathic Pulmonary Fibrosis
Section snippets
Design
The study was a retrospective cohort study that used the ISHLT registry database.
Patients
All adult patients who underwent lung transplantation from January 1, 1995, to June 30, 2002, with a diagnosis of IPF were eligible for inclusion. Patients with multiorgan transplants were excluded from the analysis because we thought that they would not be representative of the average IPF population undergoing lung transplantation. In addition, patients with unknown status at 90 days were also excluded from the
Results
From January 1, 1995, to June 30, 2002, a total of 1590 adult patients underwent lung transplantation for advanced lung disease due to IPF. Ninety-two patients were excluded because of unknown patient status at 90 days, and one was excluded because of multiorgan transplant. A total cohort of 1497 adult patients with IPF underwent lung transplantation and had 90-day follow-up reported. Of these, 667 patients did not have documented PA pressure data. This left a final cohort of 830 patients
Discussion
IPF accounts for approximately 20% of the advanced lung diseases that ultimately are treated with lung transplantation. The perioperative and long-term survival rates for patients with IPF are worse than the other most common indications for lung transplantation, emphysema and cystic fibrosis.10 The majority of long-term survival differences among these advanced lung diseases is because of significantly increased early posttransplant mortality in IPF. This group of patients may receive a
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Pulmonary hypertension in fibrosing idiopathic interstitial pneumonia: Uncertainties, challenges and opportunities
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2020, Presse MedicaleInfluence of Pulmonary Hypertension on Intrahospital Mortality in Lung Transplantation for Interstitial Lung Disease
2019, Transplantation ProceedingsCitation Excerpt :The effect of PH in the largest observational studies is not clear. Whelan et al compared the survival of lung-transplant recipients with IPF and PH and found a significantly higher risk for 90-day postoperative death in recipients with HP [3]. Hayes et al found there was no significant difference in survival for an mPAP above or below 25 mmHg [4].
Lung transplantation for idiopathic pulmonary fibrosis
2019, The Lancet Respiratory MedicineCitation Excerpt :The correlation between mean pulmonary artery pressure and survival is linear, with higher pressures associated with greater mortality.22 Post-transplantation, pulmonary hypertension is associated with an increased incidence of primary graft dysfunction and early postoperative mortality.23 However, analysis of registry data for 2542 patients with IPF suggests pulmonary hypertension might not affect long-term survival post-transplantation and this should not be a barrier to transplantation.24
Single Versus Bilateral Lung Transplantation for Idiopathic Pulmonary Fibrosis in the Lung Allocation Score Era
2019, Journal of Surgical Research