Elsevier

Journal of Cystic Fibrosis

Volume 11, Issue 5, September 2012, Pages 405-411
Journal of Cystic Fibrosis

Risk factors for rate of decline in FEV1 in adults with cystic fibrosis

https://doi.org/10.1016/j.jcf.2012.03.009Get rights and content
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Abstract

Background

Previously we assessed risk factors for FEV1 decline in children and adolescents using the Epidemiologic Study of Cystic Fibrosis (J Pediatr 2007;151:134–139); the current study assessed risk factors in adults.

Methods

Risk factors for FEV1 decline over 3–5.5 years for ages 18–24 and ≥ 25 years were assessed using mixed-model regression.

Results

Mean rates of FEV1 decline (% predicted/year) were − 1.92 for ages 18-24y (n = 2793) and − 1.45 for ages ≥ 25y (n = 1368). For the 18-24y group, B. cepacia, pancreatic enzyme use, multidrug-resistant P. aeruginosa, cough, mucoid P. aeruginosa, and female sex predicted greater decline; low baseline FEV1 and sinusitis predicted less decline. For the ≥ 25y group, only pancreatic enzyme use predicted greater decline; low baseline FEV1 and sinusitis predicted less decline.

Conclusions

Risk factors for FEV1 decline in adults < 25 years are similar to those previously identified in children and adolescents; older adults had few statistically significant risk factors.

Keywords

Cystic fibrosis
Epidemiology
FEV1
Rate of decline
Risk factors

Cited by (0)

1

For the Investigators and Coordinators of the Epidemiologic Study of Cystic Fibrosis.