Chest
Original ResearchLung InfectionLatent TB Infection Treatment Acceptance and Completion in the United States and Canada
Section snippets
Study Sites
The study was conducted at the 19 sites of the Tuberculosis Epidemiologic Studies Consortium (TBESC), each of which represents a partnership between an academic institution and a state or local TB control program.4 Each TBESC site was asked to examine practice sites in their catchment area that provided LTBI treatment to at least 10 persons in 2002 and could provide access to records of patients.
Study Design
The study design was a random stratified two-stage cluster sample survey with 1-year follow-up; all
Study Clinics and Study Subjects
Sixty-eight (68%) of the 100 clinics randomly selected for chart abstraction within the 19 catchment areas participated in the study. There were some differences between responding and nonresponding clinics. The response rate was substantially higher among public health clinics (82%) than among other types of clinics (26%); the latter group included private clinics, HIV clinics, and clinics serving homeless persons, immigrants, and refugees. There were also differences by size of clinic, with
Discussion
This study shows that although acceptance of LTBI treatment is relatively high (83%), the proportion completing is low (47%). When the product of these two proportions is calculated, we see that completion was achieved by only 39% of persons who were offered LTBI treatment. The major risk factor for noncompletion was being prescribed the 9-month INH regimen. As shown in Figure 1, when the proportions completing the three most commonly prescribed regimens are compared, it can be seen that there
Acknowledgments
Author contributions: Dr Horsburgh Jr: contributed to the design of the study, abstraction of study data, and analysis of the data, and wrote the first draft of the manuscript.
Dr Goldberg: contributed to the design of the study, analysis of the data, and preparation of the manuscript.
Dr Bethel: contributed to the design of the study, analysis of the data, and preparation of the manuscript. He had full access to all of the data in the study and takes responsibility for the integrity of the data
References (30)
- et al.
Pyrazinamide and rifampin vs isoniazid for the treatment of latent tuberculosis: improved completion rates but more hepatotoxicity
Chest
(2003) - et al.
Factors associated with the treatment of latent tuberculosis infection among health-care workers at a midwestern teaching hospital
Chest
(2002) - et al.
Predictors of failure to complete treatment for latent tuberculosis infection
J Infect
(2007) - et al.
Enhancement of treatment completion for latent tuberculosis infection with 4 months of rifampin
Chest
(2006) Targeted tuberculin testing and treatment of latent tuberculosis infection. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999. This is a Joint Statement of the American Thoracic Society (ATS) and the Centers for Disease Control and Prevention (CDC). This statement was endorsed by the Council of the Infectious Diseases Society of America. (IDSA), September 1999, and the sections of this statement
Am J Respir Crit Care Med
(2000)A strategic plan for the elimination of tuberculosis in the United States
MMWR Morb Mortal Wkly Rep
(1989)Ending Neglect. The Elimination of Tuberculosis in the United States
(2000)- et al.
The scope and impact of treatment of latent tuberculosis infection in the United States and Canada
Am J Respir Crit Care Med
(2006) - et al.
Prevalence of tuberculosis infection in the United States population: the national health and nutrition examination survey, 1999-2000
Am J Respir Crit Care Med
(2008) - et al.
Outcomes of contact investigations of infectious tuberculosis patients
Am J Respir Crit Care Med
(2000)
Treatment of latent tuberculosis infection in patients aged > or =35 years
Clin Infect Dis
Evaluation of tuberculosis contact investigations in California
Int J Tuberc Lung Dis
A tuberculin screening and isoniazid preventive therapy program in an inner-city population
Am J Respir Crit Care Med
Isoniazid prophylaxis in a slum area
Am Rev Respir Dis
Adherence to treatment for latent tuberculosis infection: systematic review of studies in the US and Canada
Int J Tuberc Lung Dis
Cited by (194)
Incidence of tuberculosis disease in individuals diagnosed with tuberculosis infection after screening: A population-based cohort study in South Korea
2024, International Journal of Infectious DiseasesPredictive capabilities of baseline radiological findings for early and late disease outcomes within sensitive and multi-drug resistant tuberculosis cases
2023, European Journal of Radiology OpenTrends in tuberculosis clinicians’ adoption of short-course regimens for latent tuberculosis infection
2023, Journal of Clinical Tuberculosis and Other Mycobacterial DiseasesVariation in Treatment of Pediatric Tuberculosis Infection in Different Provider Settings
2023, Journal of PediatricsFactors associated with non-completion of latent tuberculosis infection treatment in Rio de Janeiro, Brazil: A non-matched case control study
2022, PulmonologyCitation Excerpt :Mendonça observed a non-completion rate of 25% among subjects aged under 15 years of age who were treated in a reference unit from 2002 to 2009.12 In large series in the USA and Canada, higher rates of non-completion of LTBIT were reported (40–52%).9,22 In Salvador, Brazil, 46.5% of children and adults contacts did not complete LTBIT.10
Current Status of Latent Tuberculosis Infection Treatment Among Pediatric Patients in Korea: Prescription and Treatment Completion
2024, Journal of Korean Medical Science
Funding/Support: This study was supported by the Centers for Disease Control and Prevention, Contract Number 200-2001-00082.
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/site/misc/reprints.xhtml).