Chest
Original ResearchPulmonary Function in DiabetesPulmonary Function in Diabetes: A Metaanalysis
Section snippets
Data Sources and Searches
This metaanalysis was performed according to the guidelines of the Meta-analysis of Observational Studies in Epidemiology.13 We conducted a systematic search in PubMed (1966 through September 2009), EMBASE (1989 through September 2009), The Cochrane Library (through September 2009), and in online conference databases of the American Diabetes Association (2004-2009), European Association for the Study of Diabetes (2001-2008), International Diabetes Federation (2003), American Thoracic Society
Results
A flowchart of study selection is presented in Figure 1. Briefly, the PubMed search yielded 732 hits, from which 133 potentially relevant hits were identified. The EMBASE search yielded 498 hits, from which another 15 unique potentially relevant articles were identified. The search in The Cochrane Library did not yield any new citations. Scanning of reference lists added another 21 unique hits. Based on the abstracts from these 169 hits, we excluded 37 titles. Searches in online conference
Discussion
Our metaanalysis shows that diabetes, in the absence of overt pulmonary disease, is associated with a modest, albeit statistically significant, impaired pulmonary function in a restrictive pattern. The results were irrespective of BMI, smoking, diabetes duration, and HbA1c levels. In subanalyses, the association seemed to be more pronounced in type 2 diabetes than in type 1 diabetes. Our study adds evidence for yet another organ system to be involved in both type 1 and type 2 diabetes. As a
Acknowledgments
Author contributions: Dr van den Borst: contributed to designing the study, was responsible for data acquisition, was involved in data analyses and interpretation, compiled the original draft including tables and figures, led revisions, and was responsible for editing and final formatting.
Dr Gosker: contributed to designing the study, assisted in data analyses and interpretation of data, revised the manuscript, and assisted in technical support.
Dr Zeegers: contributed to designing the study,
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Funding/Support: This study was performed within the framework of Top Institute Pharma project T1-201. The research of Dr Gosker is supported by a grant from the Netherlands Asthma Foundation [NAF 3.4.05.038]. Dr Zeegers is sponsored by Cancer Research UK [A7098, A6135, A6835, A5738], Birmingham Children's Hospital Research Foundation, England [102f], and the Institute for the Stimulation of Innovation by Science and Technology, Belgium [070699].
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