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Clinical InvestigationsAllergen-induced Recruitment of Inflammatory Cells in Lavage 3 and 24 h After Challenge in Allergic Asthmatic Lungs
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Subjects
Twelve allergic asthmatic subjects (six women, six men) participated in the study. The clinical characteristics of the patients are given in Table 1. All asthmatic subjects were selected on the basis of positive intracutaneous skin tests to common inhalant allergens, including Dermatophagoides pteronyssinus (Diephuis, Groningen, the Netherlands) and increased specific IgE (n<0.35 PRU/ml) for house dust mite (HDM) allergen (Phadezym RAST, Pharmacia, Uppsala, Sweden) and increased bronchial
Characteristics of the Study Population
In some subjects the HDM provocation resulted in a severe early and/or late reaction; however, intervention with medication was not needed. Four patients showed only an EAR after allergen challenge and eight patients developed a dual asthmatic response (Table 1). In all patients, measurements were within baseline values. All studied subjects tolerated the bronchoscopy procedure well. The procedure did not have to be terminated in any patient and none complained of distressing dyspnea. None of
DISCUSSION
This study was designed to explore lavage findings between a steady-state period, 3 h and 24 h after a HDM challenge in single and dual asthmatic responders using BL and BAL. The number of activated (EG2)eosinophils was significantly increased at 3 h, but not the percentage of eosinophils. At 24 h both the percentage of eosinophils and the number of activated (EG2)eosinophils were increased, and at 24 h a good correlation between activated eosinophils and the percentage of eosinophils was
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Supported by Grant No 84.41 from the Nederlands Astma Fonds and a grant from DRACO AB, Lund, Sweden.
Manuscript received May 7; revision accepted August 19