Chest
Original Research: SarcoidosisIncidence of Pulmonary Hypertension and Its Clinical Relevance in Patients With Sarcoidosis
Section snippets
Study Population
The study population comprised 246 Japanese sarcoidosis patients with histologic confirmation of the diagnosis. All patients were being consecutively followed up at the outpatient sarcoidosis clinic in the Central Clinic of Kyoto during the period between August 2004 and April 2005. Patients with concurrent collagen vascular diseases or other lung diseases were excluded from the study. The following procedures were performed in the study patients. DE was used to measure sPAP, and classification
Frequency of PH
Measurement of sPAP was possible by DE in 212 of 246 patients (86%). Tricuspid regurgitant flow was absent in the rest of the subjects. Among subjects with successful PAP measurement, 12 of 212 patients (5.7%) had sPAP ≥ 40 mm Hg, which fulfilled the definition of PH.
Association of Clinical Characteristics With PH
Comparison of clinical characteristics between subjects with PH and those without PH (Table 1) showed that male gender, advanced chest radiographic stage, and decreased Spo2 were associated with PH. Treatment history, usage of
Discussion
The epidemiology of PH in sarcoidosis has not been fully elucidated due to the difficulty in performing invasive assessment of PAP in substantial number of patients with various degrees of disease severity. We investigated the frequency of PH in sarcoidosis patients who were followed up in the outpatient clinic. Clinical parameters associated with PH were also investigated.
In this study, DE was used to estimate sPAP. Although some studies19, 20 have suggested that sPAP estimated by DE does not
Acknowledgment
We thank Mr. S. Ueda, Ms. M. Aoki, Ms. M. Koshimura, and Ms. K. Tanaka for performing the Doppler echocardiography.
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This study was supported by a grant from the Smoking Research Foundation of Japan.