A clinicopathological study of lung cancer patients with occupational exposure to chrysotile asbestos fibers

Intern Med. 1999 Oct;38(10):780-4. doi: 10.2169/internalmedicine.38.780.

Abstract

Objective: To summarize the features of asbestos-related lung cancer.

Patients: Thirty-one lung cancer patients with occupational exposure to chrysotile asbestos fibers. They worked or had worked in one asbestos factory or its subcontracters.

Result: All patients were male with mean age of 60.6 when diagnosed, and all except one were current or ex-'heavy' smokers. Histological types were fairly evenly divided into adeno-, squamous and small cell carcinoma and 24 (78%) of patients showed 'peripheral type' lung cancers. Regarding clinical stages, 20 patients (65%) were classified as III or IV (advanced stage). Tumor shadow(s) was detected on chest X-ray in 22 patients (71%), and in 5 patients with 'negative' chest X-ray, chest CT was necessary to recognize a primary tumor. Seventeen patients (55%) did not undergo periodical check-ups.

Conclusion: Occupational asbestos exposure is interpreted as one of the important risks for lung cancer and frequent and accurate observation is necessary.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Asbestos / adverse effects*
  • Carcinoma / diagnosis
  • Carcinoma / etiology*
  • Humans
  • Lung Neoplasms / diagnosis
  • Lung Neoplasms / etiology*
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Occupational Diseases / diagnosis
  • Occupational Diseases / etiology*
  • Occupational Exposure / adverse effects*
  • Retrospective Studies

Substances

  • Asbestos