In order to achieve an optimal diagnostic yield in patients with endoscopically visible tumors multiple biopsies are needed. However, some centrally located necrotic endobronchial tumors and other vascular-appearing tumors are prone to bleed significantly after the first biopsy, which poses a distressed and complicated management problem for a bronchoscopist. In the present case study, a new technique, using intratumoral injection of tranexamic acid to control significant bleeding during bronchoscopic biopsy, is described. Although this study is limited to two cases, it has been suggested that good control of biopsy-induced bleeding can be attained using this technique.