Features of chronic asthma include airway hyperresponsiveness, inflammatory infiltrates,
and structural changes in the airways, termed remodeling. The contribution of eosinophils, …

To study the biologic role of migration inhibitory factor (MIF), a pleiotropic cytokine, we
generated a mouse strain lacking MIF by gene targeting in embryonic stem cells. Analysis of the …

BACKGROUND: Peripheral blood eosinophilia and lung mucosal eosinophil infiltration are
hallmarks of bronchial asthma. IL-5 is a critical cytokine for eosinophil maturation, survival, …

Innate lymphoid cells (ILCs) are critical mediators of mucosal immunity, and group 1 ILCs (ILC1
cells) and group 3 ILCs (ILC3 cells) have been shown to be functionally plastic. Here we …

CCR3 is a chemokine receptor initially thought specific to eosinophils but subsequently
identified on TH2 cell subsets, basophils, mast cells, neural tissue, and some epithelia. Because …

… Humbles and colleagues show that mice lacking interleukin-33 (IL-33) are protected from
smoke-induced exaggerated inflammatory responses to virus infection, suggesting that IL-33 is …

Asthma is a chronic inflammatory disease of the airways and lung mucosa with a strong
correlation to atopy and acquired (IgE) immunity 1 . However, many features of bronchial asthma…

BACKGROUND: Allergen exposure at lung and gut mucosae can lead to aberrant T H 2
immunity and allergic disease. The epithelium-associated cytokines thymic stromal …

Group 2 innate lymphoid cells (ILC2 cells) are important for type 2 immune responses and
are activated by the epithelial cytokines interleukin 33 (IL-33), IL-25 and thymic stromal …

Age-related macular degeneration (AMD), a leading cause of blindness worldwide, is as
prevalent as cancer in industrialized nations. Most blindness in AMD results from invasion of …