Genetics of cystic fibrosis: CFTR mutation classifications toward genotype-based CF therapies
P Fanen, A Wohlhuter-Haddad, A Hinzpeter - The international journal of …, 2014 - Elsevier
Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the cystic fibrosis
transmembrane conductance regulator (CFTR) gene, which encodes an epithelial anion …
transmembrane conductance regulator (CFTR) gene, which encodes an epithelial anion …
[HTML][HTML] Emerging therapeutic approaches for cystic fibrosis. From gene editing to personalized medicine
I Pranke, A Golec, A Hinzpeter, A Edelman… - Frontiers in …, 2019 - frontiersin.org
An improved understanding of the cystic fibrosis (CF) transmembrane conductance regulator
(CFTR) protein structure and the consequences of CFTR gene mutations have allowed the …
(CFTR) protein structure and the consequences of CFTR gene mutations have allowed the …
Modulators of CFTR. Updates on clinical development and future directions
…, B Chevalier, F Berhal, G Prestat, A Hinzpeter… - European journal of …, 2021 - Elsevier
Cystic fibrosis (CF) is the most frequent life-limiting autosomal recessive disorder in the
Caucasian population. It is due to mutations in the Cystic Fibrosis Transmembrane Conductance …
Caucasian population. It is due to mutations in the Cystic Fibrosis Transmembrane Conductance …
[HTML][HTML] Correction of CFTR function in nasal epithelial cells from cystic fibrosis patients predicts improvement of respiratory function by CFTR modulators
…, M Mesbahi, E Girodon-Boulandet, A Hinzpeter… - Scientific reports, 2017 - nature.com
Clinical studies with modulators of the Cystic Fibrosis Transmembrane conductance Regulator
(CFTR) protein have demonstrated that functional restoration of the mutated CFTR can …
(CFTR) protein have demonstrated that functional restoration of the mutated CFTR can …
Prevention of interferon-alpha associated depression in psychiatric risk patients with chronic hepatitis C
…, M Schwaiger, AS Garkisch, M Pich, A Hinzpeter… - Journal of …, 2005 - Elsevier
Background/Aims: Interferon-alpha (IFN-α) induced depression is a major limitation for the
treatment of chronic hepatitis C, especially for patients with psychiatric disorders. We …
treatment of chronic hepatitis C, especially for patients with psychiatric disorders. We …
[PDF][PDF] Hepatitis C treatment in “difficult‐to‐treat” psychiatric patients with pegylated interferon‐alpha and ribavirin: response and psychiatric side effects
M Schaefer, A Hinzpeter, A Mohmand, G Janssen… - …, 2007 - Wiley Online Library
We investigated and compared the results of treating the chronic hepatitis C (HCV) infection
of different groups of psychiatric‐risk patients and controls with pegylated interferon alpha (…
of different groups of psychiatric‐risk patients and controls with pegylated interferon alpha (…
Evidence for direct CFTR inhibition by CFTRinh-172 based on Arg347 mutagenesis
E Caci, A Caputo, A Hinzpeter, N Arous… - Biochemical …, 2008 - portlandpress.com
CFTR (cystic fibrosis transmembrane conductance regulator) is an epithelial Cl − channel
inhibited with high affinity and selectivity by the thiazolidinone compound CFTR inh -172. In …
inhibited with high affinity and selectivity by the thiazolidinone compound CFTR inh -172. In …
Pharmacological chaperones improve intra-domain stability and inter-domain assembly via distinct binding sites to rescue misfolded CFTR
…, I Sermet-Gaudelus, I Callebaut, A Hinzpeter - Cellular and Molecular …, 2021 - Springer
Protein misfolding is involved in a large number of diseases, among which cystic fibrosis.
Complex intra- and inter-domain folding defects associated with mutations in the cystic fibrosis …
Complex intra- and inter-domain folding defects associated with mutations in the cystic fibrosis …
[HTML][HTML] Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis
…, JP Vrel, V Urbach, N Baatallah, A Hinzpeter… - Scientific reports, 2019 - nature.com
Cystic fibrosis (CF) is caused by defective Cystic Fibrosis Transmembrane Conductance
Regulator (CFTR) protein. Morbidity is mainly due to early airway infection. We hypothesized …
Regulator (CFTR) protein. Morbidity is mainly due to early airway infection. We hypothesized …
Theratyping cystic fibrosis patients to guide elexacaftor/tezacaftor/ivacaftor out-of-label prescription
…, C Marguet, A Edelman, A Hinzpeter… - European …, 2023 - Eur Respiratory Soc
Background Around 20% of people with cystic fibrosis (pwCF) do not have access to the triple
combination elexacaftor/tezacaftor/ivacaftor (ETI) in Europe because they do not carry the …
combination elexacaftor/tezacaftor/ivacaftor (ETI) in Europe because they do not carry the …