Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations

A Papi, CM Bellettato, F Braccioni… - American journal of …, 2006 - atsjournals.org
Rationale: Severe exacerbations of chronic obstructive pulmonary disease (COPD) are
major causes of health care costs mostly related to hospitalization. The role of infections in …

Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease: the GOLD science committee report 2019

…, F Martinez, MM de Oca, A Papi… - European …, 2019 - Eur Respiratory Soc
Precision medicine is a patient-specific approach that integrates all relevant clinical, genetic
and biological information in order to optimise the therapeutic benefit relative to the …

Management of COPD exacerbations: a European respiratory society/American thoracic society guideline

…, RK Albert, A Anzueto, GJ Criner, A Papi… - European …, 2017 - Eur Respiratory Soc
This document provides clinical recommendations for treatment of chronic obstructive
pulmonary disease (COPD) exacerbations. Comprehensive evidence syntheses, including meta-…

European Respiratory Society guidelines for the diagnosis of asthma in adults

…, M Thomas, M Idzko, A Papi… - European …, 2022 - Eur Respiratory Soc
Although asthma is very common, affecting 5–10% of the population, the diagnosis of
asthma in adults remains a challenge in the real world, which results in both over- and under-…

Global initiative for the diagnosis, management, and prevention of chronic obstructive lung disease. The 2020 GOLD science committee report on COVID-19 and …

DMG Halpin, GJ Criner, A Papi, D Singh… - American journal of …, 2021 - atsjournals.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has raised
many questions about the management of patients with chronic obstructive pulmonary …

An official American Thoracic Society/European Respiratory Society statement: research questions in chronic obstructive pulmonary disease

…, M Miravitlles, PM Meek, A Papi… - American journal of …, 2015 - atsjournals.org
Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity,
mortality, and resource use worldwide. The goal of this Official American Thoracic Society (…

Respiratory syncytial virus prefusion F protein vaccine in older adults

A Papi, MG Ison, JM Langley, DG Lee… - … England Journal of …, 2023 - Mass Medical Soc
Background Respiratory syncytial virus (RSV) is an important cause of acute respiratory
infection, lower respiratory tract disease, clinical complications, and death in older adults. There …

Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2-agonists (SIROCCO): a …

ER Bleecker, JM FitzGerald, P Chanez, A Papi… - The Lancet, 2016 - thelancet.com
Background Eosinophilia is associated with worsening asthma severity and decreased lung
function, with increased exacerbation frequency. We assessed the safety and efficacy of …

Role of deficient type III interferon-λ production in asthma exacerbations

…, ST Holgate, DE Davies, SV Kotenko, A Papi… - Nature medicine, 2006 - nature.com
Rhinoviruses are the major cause of asthma exacerbations, and asthmatics have increased
susceptibility to rhinovirus and risk of invasive bacterial infections. Here we show deficient …

Dupilumab for COPD with type 2 inflammation indicated by eosinophil counts

…, M Bafadhel, SA Christenson, A Papi… - … England Journal of …, 2023 - Mass Medical Soc
Background In some patients with chronic obstructive pulmonary disease (COPD), type 2
inflammation may increase exacerbation risk and may be indicated by elevated blood …